Literature DB >> 3367920

Utilization of the quantitative component of positive and negative results of short-term tests.

S Parodi1, M Taningher, L Santi.   

Abstract

In this paper we discuss the possibility of utilizing not only the qualitative component of the information obtained from long-term and short-term tests (as is customary), but also the quantitative component of the results. We suggest that there is probably a precise mathematical relationship between the qualitative and quantitative approaches. We show that utilizing the quantitative approach, it is possible to give confidence limits to a given prediction, a possibility potentially very useful for risk evaluation. We show that starting from a reasonable working hypothesis, it is possible to include even negative data in a unified quantitative approach. Incorporating the quantitative component of the information could offer appreciable gains in predictivity, especially when utilizing batteries of tests.

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Year:  1988        PMID: 3367920     DOI: 10.1016/0165-1218(88)90023-7

Source DB:  PubMed          Journal:  Mutat Res        ISSN: 0027-5107            Impact factor:   2.433


  3 in total

1.  Quantitative predictability of carcinogenicity of the covalent binding index of chemicals to DNA: comparison of the in vivo and in vitro assays.

Authors:  M Taningher; G Saccomanno; L Santi; S Grilli; S Parodi
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031

2.  Examples of uses of databases for quantitative and qualitative correlation studies between genotoxicity and carcinogenicity.

Authors:  S Parodi; D Malacarne; M Taningher
Journal:  Environ Health Perspect       Date:  1991-12       Impact factor: 9.031

Review 3.  Predicting the carcinogenicity of chemicals in humans from rodent bioassay data.

Authors:  G Goodman; R Wilson
Journal:  Environ Health Perspect       Date:  1991-08       Impact factor: 9.031

  3 in total

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