Hiroyuki Kitano1, Chizu Sanjoba2, Yasuyuki Goto2, Kazumasa Iwamoto3, Hiroki Kitagawa4, Toshihito Nomura4, Keitaro Omori4, Norifumi Shigemoto4, Michihiro Hide3, Yoshitsugu Matsumoto2, Hiroki Ohge4. 1. Department of Infectious Diseases, Hiroshima University Hospital, 1-2-3 Minamiku Kasumi, Minamiku, Hiroshima City, Hiroshima, 734-8551, Japan. tanokin@hiroshima-u.ac.jp. 2. Laboratory of Molecular Immunology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, Tokyo University, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, Tokyo, 113-8657, Japan. 3. Department of Dermatology, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Minamiku Kasumi, Minamiku, Hiroshima City, Hiroshima, 734-8551, Japan. 4. Department of Infectious Diseases, Hiroshima University Hospital, 1-2-3 Minamiku Kasumi, Minamiku, Hiroshima City, Hiroshima, 734-8551, Japan.
Abstract
BACKGROUND: Leishmaniasis is not endemic in Japan, and imported cases are rare. However, there are increasing concerns regarding imported cases of cutaneous leishmaniasis from endemic countries to Japan. This report describes a case of imported cutaneous leishmaniasis that was diagnosed and treated in Japan. CASE PRESENTATION: A 53-year-old Pakistani man presented with skin lesions on both malleoli of his right ankle and the dorsum of the left foot. The skin lesions manifested as erythematous nodules surrounding an ulcer in the center of the lesion. The lesions of the malleoli of his right ankle each measured 3 × 3 cm, and the lesion on the top of his left foot measured 5 × 4 cm. He had been living and working in Japan but had a history of a visit to Pakistan for about 2 months in 2018. The skin lesions were biopsied. Giemsa and hematoxylin and eosin staining of biopsy samples showed amastigotes of Leishmania in macrophages, and the presence of Leishmania was confirmed by skin tissue culture. Polymerase chain reaction using biopsy specimens identified Leishmania parasites, and DNA sequence analysis revealed that the species was Leishmania tropica. The patient was treated with intravenous liposomal amphotericin B for 6 days. The erythema disappeared, and the erythematous nodules resolved within 3 weeks. CONCLUSION: This is the first report of imported cutaneous leishmaniasis caused by L. tropica from Pakistan, and it is interesting that all three testing modalities showed positive results in this case.
BACKGROUND:Leishmaniasis is not endemic in Japan, and imported cases are rare. However, there are increasing concerns regarding imported cases of cutaneous leishmaniasis from endemic countries to Japan. This report describes a case of imported cutaneous leishmaniasis that was diagnosed and treated in Japan. CASE PRESENTATION: A 53-year-old Pakistani man presented with skin lesions on both malleoli of his right ankle and the dorsum of the left foot. The skin lesions manifested as erythematous nodules surrounding an ulcer in the center of the lesion. The lesions of the malleoli of his right ankle each measured 3 × 3 cm, and the lesion on the top of his left foot measured 5 × 4 cm. He had been living and working in Japan but had a history of a visit to Pakistan for about 2 months in 2018. The skin lesions were biopsied. Giemsa and hematoxylin and eosin staining of biopsy samples showed amastigotes of Leishmania in macrophages, and the presence of Leishmania was confirmed by skin tissue culture. Polymerase chain reaction using biopsy specimens identified Leishmania parasites, and DNA sequence analysis revealed that the species was Leishmania tropica. The patient was treated with intravenous liposomal amphotericin B for 6 days. The erythema disappeared, and the erythematous nodules resolved within 3 weeks. CONCLUSION: This is the first report of imported cutaneous leishmaniasis caused by L. tropica from Pakistan, and it is interesting that all three testing modalities showed positive results in this case.
Authors: Mubbashir Hussain; Shahzad Munir; Sultan Ayaz; Bahar Ullah Khattak; Taj Ali Khan; Niaz Muhammad; Muhammad Anees; Hazir Rahman; Muhammad Qasim; Muhammad Ameen Jamal; Irfan Ahmed; Kashif Rahim; Humaira Mazhar; Noha Watanay; Mohamed Kasbari Journal: Asian Pac J Trop Med Date: 2017-07-27 Impact factor: 1.226
Authors: Freddie Bailey; Karina Mondragon-Shem; Lee Rafuse Haines; Amina Olabi; Ahmed Alorfi; José Antonio Ruiz-Postigo; Jorge Alvar; Peter Hotez; Emily R Adams; Iván D Vélez; Waleed Al-Salem; Julian Eaton; Álvaro Acosta-Serrano; David H Molyneux Journal: PLoS Negl Trop Dis Date: 2019-02-25
Authors: Katarzyna Sikorska; Marta Gesing; Romuald Olszański; Anna Roszko-Wysokińska; Beata Szostakowska; Katarzyna Van Damme-Ostapowicz Journal: Trop Dis Travel Med Vaccines Date: 2022-08-01