Elena Succurro1, Sofia Miceli2, Teresa Vanessa Fiorentino2, Angela Sciacqua2, Maria Perticone2, Francesco Andreozzi2, Giorgio Sesti3. 1. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. succurro@unicz.it. 2. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. 3. Department of Clinical and Molecular Medicine, University of Rome-Sapienza, 00189, Rome, Italy.
Abstract
BACKGROUND: Women with type 2 diabetes (T2DM) have a higher excess risk for cardiovascular disease (CVD) than their male counterparts. However, whether the risk for CVD is higher in prediabetic women than men is still debated. We aimed to determine whether sex-related differences exist in left ventricular mass index (LVMI), and myocardial mechano-energetic efficiency (MEEi) in with normal glucose tolerant (NGT), pre-diabetic and newly diagnosed type 2 diabetic subjects. METHODS: Sex-related differences in LVMI and myocardial MEEi, assessed by validated echocardiography-derived measures, were examined among 1562 adults with NGT, prediabetes, and newly diagnosed T2DM, defined according to fasting glucose, 2-h post-load glucose, or HbA1c. RESULTS: Worsening of glucose tolerance in both men and women was associated with an increase in age-adjusted LVMI and myocardial MEEi. Women with newly diagnosed T2DM exhibited greater relative differences in LVMI and myocardial MEEi than diabetic men when compared with their NGT counterparts. Prediabetic women exhibited greater relative differences in myocardial MEEi, but not in LVMI, than prediabetic men when compared with their NGT counterparts. The statistical test for interaction between sex and glucose tolerance on both LVMI (P < 0.0001), and myocardial MEEi (P < 0.0001) was significant suggesting a sex-specific association. CONCLUSIONS: Left ventricle is subject to maladaptive changes with worsening of glucose tolerance, especially in women with newly diagnosed T2DM. The sex-specific increase in LVM and decrease in MEEi, both being predictors of CVD, may have a role in explaining the stronger impact of T2DM on the excess risk of CVD in women than in men.
BACKGROUND:Women with type 2 diabetes (T2DM) have a higher excess risk for cardiovascular disease (CVD) than their male counterparts. However, whether the risk for CVD is higher in prediabetic women than men is still debated. We aimed to determine whether sex-related differences exist in left ventricular mass index (LVMI), and myocardial mechano-energetic efficiency (MEEi) in with normal glucose tolerant (NGT), pre-diabetic and newly diagnosed type 2 diabetic subjects. METHODS: Sex-related differences in LVMI and myocardial MEEi, assessed by validated echocardiography-derived measures, were examined among 1562 adults with NGT, prediabetes, and newly diagnosed T2DM, defined according to fasting glucose, 2-h post-load glucose, or HbA1c. RESULTS: Worsening of glucose tolerance in both men and women was associated with an increase in age-adjusted LVMI and myocardial MEEi. Women with newly diagnosed T2DM exhibited greater relative differences in LVMI and myocardial MEEi than diabeticmen when compared with their NGT counterparts. Prediabetic women exhibited greater relative differences in myocardial MEEi, but not in LVMI, than prediabetic men when compared with their NGT counterparts. The statistical test for interaction between sex and glucose tolerance on both LVMI (P < 0.0001), and myocardial MEEi (P < 0.0001) was significant suggesting a sex-specific association. CONCLUSIONS: Left ventricle is subject to maladaptive changes with worsening of glucose tolerance, especially in women with newly diagnosed T2DM. The sex-specific increase in LVM and decrease in MEEi, both being predictors of CVD, may have a role in explaining the stronger impact of T2DM on the excess risk of CVD in women than in men.
Entities:
Keywords:
Cardiovascular disease; Left ventricular mass; Myocardial mechano-energetic efficiency; Prediabetes; Sex-differences; Type 2 diabetes
Authors: Giovanni de Simone; Jorge R Kizer; Marcello Chinali; Mary J Roman; Jonathan N Bella; Lyle G Best; Elisa T Lee; Richard B Devereux Journal: Am J Hypertens Date: 2005-02 Impact factor: 2.689
Authors: Angela Sciacqua; Sofia Miceli; Giuseppe Carullo; Laura Greco; Elena Succurro; Franco Arturi; Giorgio Sesti; Francesco Perticone Journal: Diabetes Care Date: 2011-04-22 Impact factor: 19.112
Authors: Angela Sciacqua; Sofia Miceli; Laura Greco; Franco Arturi; Paola Naccarato; Deborah Mazzaferro; Eliezer J Tassone; Laura Turano; Francesco Martino; Giorgio Sesti; Francesco Perticone Journal: Diabetes Care Date: 2011-09-12 Impact factor: 19.112
Authors: Ana Lopez-de-Andres; Rodrigo Jimenez-Garcia; Valentin Hernández-Barrera; Javier de-Miguel-Díez; Jose M de-Miguel-Yanes; David Martinez-Hernandez; David Carabantes-Alarcon; Jose J Zamorano-Leon; Concepción Noriega Journal: Cardiovasc Diabetol Date: 2022-09-30 Impact factor: 8.949