Jean-Baptiste Bouillon-Minois1,2, Marion Trousselard3, David Thivel4, Brett Ashley Gordon5, Jeannot Schmidt1,2, Farès Moustafa6, Charlotte Oris7,8, Frédéric Dutheil1,9. 1. Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, F-63000 Clermont-Ferrand, France. 2. CHU Clermont-Ferrand, Emergency Medicine, F-63000 Clermont-Ferrand, France. 3. French Armed Forces Biomedical Research Institute, IRBA, Neurophysiology of Stress, Neuroscience and Operational Constraint Department, F-91223 Brétigny-sur-Orge, France. 4. Université Clermont Auvergne, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological conditions [AME2P], F-63000 Clermont Ferrand, France. 5. La Trobe University, Holsworth Research Initiative, Bendigo, 3083 Victoria, Australia. 6. University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Emergency Medicine, F-63000 Clermont-Ferrand, France. 7. Université Clermont Auvergne, CNRS, INSERM, GReD, F-63000, Clermont-Ferrand, France. 8. CHU Clermont-Ferrand, Biochemistry and Molecular Genetic Department, F-63000 Clermont-Ferrand, France. 9. CHU Clermont-Ferrand, Occupational and Environmental Medicine, WittyFit, F-63000 Clermont-Ferrand, France.
Abstract
INTRODUCTION: Ghrelin is an orexigenic hormone which favors food-seeking behavior and has been postulated to be a biomarker of stress. We conducted a systematic review and meta-analysis on the evolution of ghrelin levels following acute stress. METHODS: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched for studies reporting ghrelin levels before and after acute stress in humans. RESULTS: We included ten studies for a total of 348 patients. Acute stress (intervention) was always in a laboratory. Acute stress was psychological (Trier Social Stress Test), physical, or mixed (cold pressure test). The overall meta-analysis demonstrated an increase in ghrelin after the stress intervention (ES = 0.21, 95CI 0.09 to 0.34) compared with baseline levels. Stratification by time demonstrated an acute increase in ghrelin levels in the five minutes immediately following the initiation of stress (0.29, 0.10 to 0.48) but without any difference after. Obese individuals had a more significant (ES = 0.51, 95CI 0.18 to 0.84) and prolonged increase in ghrelin levels for up to 45 min compared with non-obese individuals who had a significant increase only five minutes after stress. Moreover, the ghrelin levels increased in response to stress with BMI (coefficient 0.028, 0.01 to 0.49; p = 0.013) and decreased with the time after the stress intervention (coefficient -0.007, -0.014 to -0.001; p = 0.025). CONCLUSION: Ghrelin is a biomarker of stress, with a short-term increase following acute stress. Obese individuals have both a higher and prolonged response, emphasizing the link between obesity and stress.
INTRODUCTION:Ghrelin is an orexigenic hormone which favors food-seeking behavior and has been postulated to be a biomarker of stress. We conducted a systematic review and meta-analysis on the evolution of ghrelin levels following acute stress. METHODS: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched for studies reporting ghrelin levels before and after acute stress in humans. RESULTS: We included ten studies for a total of 348 patients. Acute stress (intervention) was always in a laboratory. Acute stress was psychological (Trier Social Stress Test), physical, or mixed (cold pressure test). The overall meta-analysis demonstrated an increase in ghrelin after the stress intervention (ES = 0.21, 95CI 0.09 to 0.34) compared with baseline levels. Stratification by time demonstrated an acute increase in ghrelin levels in the five minutes immediately following the initiation of stress (0.29, 0.10 to 0.48) but without any difference after. Obese individuals had a more significant (ES = 0.51, 95CI 0.18 to 0.84) and prolonged increase in ghrelin levels for up to 45 min compared with non-obese individuals who had a significant increase only five minutes after stress. Moreover, the ghrelin levels increased in response to stress with BMI (coefficient 0.028, 0.01 to 0.49; p = 0.013) and decreased with the time after the stress intervention (coefficient -0.007, -0.014 to -0.001; p = 0.025). CONCLUSION:Ghrelin is a biomarker of stress, with a short-term increase following acute stress. Obese individuals have both a higher and prolonged response, emphasizing the link between obesity and stress.
Entities:
Keywords:
anxiety; appetite; mental health; metabolism; public health
Authors: J Douglas Bremner; Kasra Moazzami; Matthew T Wittbrodt; Jonathon A Nye; Bruno B Lima; Charles F Gillespie; Mark H Rapaport; Bradley D Pearce; Amit J Shah; Viola Vaccarino Journal: Nutrients Date: 2020-08-13 Impact factor: 5.717
Authors: Jean-Baptiste Bouillon-Minois; Marion Trousselard; Bruno Pereira; Jeannot Schmidt; Maelys Clinchamps; David Thivel; Ukadike Chris Ugbolue; Farès Moustafa; Céline Occelli; Guillaume Vallet; Frédéric Dutheil Journal: Int J Environ Res Public Health Date: 2021-04-12 Impact factor: 3.390