Literature DB >> 33670027

Residual Proviral Reservoirs: A High Risk for HIV Persistence and Driving Forces for Viral Rebound after Analytical Treatment Interruption.

Xiaolei Wang1, Huanbin Xu1.   

Abstract

Antiretroviral therapy (ART) has dramatically suppressed human immunodeficiency virus (HIV) replication and become undetectable viremia. However, a small number of residual replication-competent HIV proviruses can still persist in a latent state even with lifelong ART, fueling viral rebound in HIV-infected patient subjects after treatment interruption. Therefore, the proviral reservoirs distributed in tissues in the body represent a major obstacle to a cure for HIV infection. Given unavailable HIV vaccine and a failure to eradicate HIV proviral reservoirs by current treatment, it is crucial to develop new therapeutic strategies to eliminate proviral reservoirs for ART-free HIV remission (functional cure), including a sterilizing cure (eradication of HIV reservoirs). This review highlights recent advances in the establishment and persistence of HIV proviral reservoirs, their detection, and potential eradication strategies.

Entities:  

Keywords:  HIV; SIV; cell-associated viral reservoir; proviral reservoir

Mesh：

Substances：

Year:  2021        PMID： 33670027      PMCID： PMC7926539          DOI： 10.3390/v13020335

Source DB:  PubMed          Journal:  Viruses        ISSN： 1999-4915            Impact factor:   5.048


  198 in total

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Authors:  Kaitlin Rainwater-Lovett; Katherine Luzuriaga; Deborah Persaud
Journal:  Curr Opin HIV AIDS       Date:  2015-01       Impact factor: 4.283

2.  Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.

Authors:  Angela M Mexas; Erin H Graf; Matthew J Pace; Jianqing J Yu; Emmanouil Papasavvas; Livio Azzoni; Michael P Busch; Michele Di Mascio; Andrea S Foulkes; Stephen A Migueles; Luis J Montaner; Una O'Doherty
Journal:  AIDS       Date:  2012-11-28       Impact factor: 4.177

3.  Infrequent HIV Infection of Circulating Monocytes during Antiretroviral Therapy.

Authors:  Marta Massanella; Wendy Bakeman; Pasiri Sithinamsuwan; James L K Fletcher; Nitiya Chomchey; Somporn Tipsuk; Thep Chalermchai; Jean-Pierre Routy; Jintanat Ananworanich; Victor G Valcour; Nicolas Chomont
Journal:  J Virol       Date:  2019-12-12       Impact factor: 5.103

Review 4.  Paediatric HIV infection: the potential for cure.

Authors:  Philip J Goulder; Sharon R Lewin; Ellen M Leitman
Journal:  Nat Rev Immunol       Date:  2016-03-14       Impact factor: 53.106

5.  Longitudinal study reveals HIV-1-infected CD4+ T cell dynamics during long-term antiretroviral therapy.

Authors:  Annukka Ar Antar; Katharine M Jenike; Sunyoung Jang; Danielle N Rigau; Daniel B Reeves; Rebecca Hoh; Melissa R Krone; Jeanne C Keruly; Richard D Moore; Joshua T Schiffer; Bareng As Nonyane; Frederick M Hecht; Steven G Deeks; Janet D Siliciano; Ya-Chi Ho; Robert F Siliciano
Journal:  J Clin Invest       Date:  2020-07-01       Impact factor: 14.808

6.  High levels of CD2 expression identify HIV-1 latently infected resting memory CD4+ T cells in virally suppressed subjects.

Authors:  Maria Iglesias-Ussel; Claire Vandergeeten; Luigi Marchionni; Nicolas Chomont; Fabio Romerio
Journal:  J Virol       Date:  2013-06-12       Impact factor: 5.103

7.  Predictors of SIV recrudescence following antiretroviral treatment interruption.

Authors:  Mykola Pinkevych; Christine M Fennessey; Deborah Cromer; Carolyn Reid; Charles M Trubey; Jeffrey D Lifson; Brandon F Keele; Miles P Davenport
Journal:  Elife       Date:  2019-10-25       Impact factor: 8.140

8.  Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants.

Authors:  Mark D Pankau; Dalton Wamalwa; Sarah Benki-Nugent; Kenneth Tapia; Evelyn Ngugi; Agnes Langat; Vincent Otieno; Helen Moraa; Elizabeth Maleche-Obimbo; Julie Overbaugh; Grace C John-Stewart; Dara A Lehman
Journal:  Open Forum Infect Dis       Date:  2017-12-09       Impact factor: 3.835

Review 9.  Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection.

Authors:  Matthew S Parsons; Roger Le Grand; Stephen J Kent
Journal:  Viruses       Date:  2018-06-18       Impact factor: 5.048

Review 10.  Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.

Authors:  Johann Plantin; Marta Massanella; Nicolas Chomont
Journal:  Retrovirology       Date:  2018-01-17       Impact factor: 4.602
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  4 in total

1.  Systemic and Intestinal Viral Reservoirs in CD4+ T Cell Subsets in Primary SIV Infection.

Authors:  Xiaolei Wang; Widade Ziani; Ronald S Veazey; Huanbin Xu
Journal:  Viruses       Date:  2021-11-30       Impact factor: 5.048

Review 2.  Two-Drug Regimens for HIV-Current Evidence, Research Gaps and Future Challenges.

Authors:  Alexandre Pérez-González; Inés Suárez-García; Antonio Ocampo; Eva Poveda
Journal:  Microorganisms       Date:  2022-02-14

3.  Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth.

Authors:  Xiaolei Wang; Eunice Vincent; Summer Siddiqui; Katherine Turnbull; Hong Lu; Robert Blair; Xueling Wu; Meagan Watkins; Widade Ziani; Jiasheng Shao; Lara A Doyle-Meyers; Kasi E Russell-Lodrigue; Rudolf P Bohm; Ronald S Veazey; Huanbin Xu
Journal:  Nat Commun       Date:  2022-08-16       Impact factor: 17.694

4.  Highly Efficient Autologous HIV-1 Isolation by Coculturing Macrophage With Enriched CD4+ T Cells From HIV-1 Patients.

Authors:  Cristina Xufré; Tanía González; Lorna Leal; Charles M Trubey; Jeffrey D Lifson; José María Gatell; José Alcamí; Núria Climent; Felipe García; Sonsoles Sánchez-Palomino
Journal:  Front Virol       Date:  2022-04-07
  4 in total

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