Literature DB >> 26972723

Paediatric HIV infection: the potential for cure.

Philip J Goulder1, Sharon R Lewin2,3, Ellen M Leitman1.   

Abstract

Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.

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Year:  2016        PMID： 26972723      PMCID： PMC5694689          DOI： 10.1038/nri.2016.19

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  164 in total

1.  Absence of detectable viremia in a perinatally HIV-1-infected teenager after discontinuation of antiretroviral therapy.

Authors:  Margaret E Feeney; Yanhua Tang; Almas Rathod; Catherine Kneut; Kenneth McIntosh
Journal:  J Allergy Clin Immunol       Date:  2006-07-03       Impact factor: 10.793

2.  Rapid viral rebound after 4 years of suppressive therapy in a seronegative HIV-1 infected infant treated from birth.

Authors:  Karina M Butler; Patrick Gavin; Suzie Coughlan; Annette Rochford; Sinead Mc Donagh; Orla Cunningham; Hannah Poulsom; Sarah A Watters; Nigel Klein
Journal:  Pediatr Infect Dis J       Date:  2015-03       Impact factor: 2.129

3.  Incident HIV infection in pregnant and lactating women and its effect on mother-to-child transmission in South Africa.

Authors:  Dhayendre Moodley; Tonya Esterhuizen; Logan Reddy; Pravi Moodley; Bipraj Singh; Linda Ngaleka; Devan Govender
Journal:  J Infect Dis       Date:  2011-03-11       Impact factor: 5.226

4.  Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.

Authors:  Julian H Elliott; James H McMahon; Christina C Chang; Sulggi A Lee; Wendy Hartogensis; Namandje Bumpus; Rada Savic; Janine Roney; Rebecca Hoh; Ajantha Solomon; Michael Piatak; Robert J Gorelick; Jeff Lifson; Peter Bacchetti; Steven G Deeks; Sharon R Lewin
Journal:  Lancet HIV       Date:  2015-11-17       Impact factor: 12.767

5.  Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.

Authors:  K C Ngumbela; C L Day; Z Mncube; K Nair; D Ramduth; C Thobakgale; E Moodley; S Reddy; C de Pierres; N Mkhwanazi; K Bishop; M van der Stok; N Ismail; I Honeyborne; H Crawford; D G Kavanagh; C Rousseau; D Nickle; J Mullins; D Heckerman; B Korber; H Coovadia; P Kiepiela; P J R Goulder; B D Walker
Journal:  AIDS Res Hum Retroviruses       Date:  2008-01       Impact factor: 2.205

6.  Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.

Authors:  E M Connor; R S Sperling; R Gelber; P Kiselev; G Scott; M J O'Sullivan; R VanDyke; M Bey; W Shearer; R L Jacobson
Journal:  N Engl J Med       Date:  1994-11-03       Impact factor: 91.245

7.  Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.

Authors:  Philippa C Matthews; Andrew Prendergast; Alasdair Leslie; Hayley Crawford; Rebecca Payne; Christine Rousseau; Morgane Rolland; Isobella Honeyborne; Jonathan Carlson; Carl Kadie; Christian Brander; Karen Bishop; Nonkululeko Mlotshwa; James I Mullins; Hoosen Coovadia; Thumbi Ndung'u; Bruce D Walker; David Heckerman; Philip J R Goulder
Journal:  J Virol       Date:  2008-07-02       Impact factor: 5.103

8.  Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.

Authors:  Pablo Tebas; David Stein; Winson W Tang; Ian Frank; Shelley Q Wang; Gary Lee; S Kaye Spratt; Richard T Surosky; Martin A Giedlin; Geoff Nichol; Michael C Holmes; Philip D Gregory; Dale G Ando; Michael Kalos; Ronald G Collman; Gwendolyn Binder-Scholl; Gabriela Plesa; Wei-Ting Hwang; Bruce L Levine; Carl H June
Journal:  N Engl J Med       Date:  2014-03-06       Impact factor: 91.245

9.  Neonatal innate TLR-mediated responses are distinct from those of adults.

Authors:  Tobias R Kollmann; Juliet Crabtree; Annie Rein-Weston; Darren Blimkie; Francis Thommai; Xiu Yu Wang; Pascal M Lavoie; Jeff Furlong; Edgardo S Fortuno; Adeline M Hajjar; Natalie R Hawkins; Steven G Self; Christopher B Wilson
Journal:  J Immunol       Date:  2009-11-16       Impact factor: 5.422

10.  LILRB2 interaction with HLA class I correlates with control of HIV-1 infection.

Authors:  Arman A Bashirova; Enrique Martin-Gayo; Des C Jones; Ying Qi; Richard Apps; Xiaojiang Gao; Patrick S Burke; Craig J Taylor; Jerome Rogich; Steven Wolinsky; Jay H Bream; Priya Duggal; Shehnaz Hussain; Jeremy Martinson; Amy Weintrob; Gregory D Kirk; Jacques Fellay; Susan P Buchbinder; James J Goedert; Steven G Deeks; Florencia Pereyra; John Trowsdale; Mathias Lichterfeld; Amalio Telenti; Bruce D Walker; Rachel L Allen; Mary Carrington; Xu G Yu
Journal:  PLoS Genet       Date:  2014-03-06       Impact factor: 5.917
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  55 in total

Review 1.  Pediatric HIV: the Potential of Immune Therapeutics to Achieve Viral Remission and Functional Cure.

Authors:  Stella J Berendam; Ashley N Nelson; Ria Goswami; Deborah Persaud; Nancy L Haigwood; Ann Chahroudi; Genevieve G Fouda; Sallie R Permar
Journal:  Curr HIV/AIDS Rep       Date:  2020-06       Impact factor: 5.071

2.  12-month outcomes of HIV-infected infants identified at birth at one maternity site in Johannesburg, South Africa: an observational cohort study.

Authors:  Karl-Günter Technau; Renate Strehlau; Faeezah Patel; Stephanie Shiau; Megan Burke; Martie Conradie; Gillian Sorour; Gayle G Sherman; Ashraf Coovadia; Pamela M Murnane; Elaine J Abrams; Louise Kuhn
Journal:  Lancet HIV       Date:  2018-11-08       Impact factor: 12.767

3.  An HIV-1 Broadly Neutralizing Antibody from a Clade C-Infected Pediatric Elite Neutralizer Potently Neutralizes the Contemporaneous and Autologous Evolving Viruses.

Authors:  Harekrushna Panda; Muzamil Ashraf Makhdoomi; Nitesh Mishra; Sanjeev Kumar; Haaris Ahsan Safdari; Himanshi Chawla; Heena Aggarwal; Elluri Seetharami Reddy; Rakesh Lodha; Sushil Kumar Kabra; Anmol Chandele; Somnath Dutta; Kalpana Luthra
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

4.  Differences in inducibility of the latent HIV reservoir in perinatal and adult infection.

Authors:  Adit Dhummakupt; Jessica H Rubens; Thuy Anderson; Laura Powell; Bareng As Nonyane; Lilly V Siems; Aleisha Collinson-Streng; Tricia Nilles; R Brad Jones; Vicki Tepper; Allison Agwu; Deborah Persaud
Journal:  JCI Insight       Date:  2020-02-27

Review 5.  The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV.

Authors:  Paolo Palma; Margaret McManus; Nicola Cotugno; Salvatore Rocca; Paolo Rossi; Katherine Luzuriaga
Journal:  Lancet HIV       Date:  2020-05       Impact factor: 12.767

6.  Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes.

Authors:  Ashley N Nelson; Ria Goswami; Maria Dennis; Joshua Tu; Riley J Mangan; Pooja T Saha; Derek W Cain; Alan D Curtis; Xiaoying Shen; George M Shaw; Katharine Bar; Michael Hudgens; Justin Pollara; Kristina De Paris; Koen K A Van Rompay; Sallie R Permar
Journal:  J Virol       Date:  2019-07-17       Impact factor: 5.103

7.  HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.

Authors:  Amélie Cattin; Tomas Raul Wiche Salinas; Annie Gosselin; Delphine Planas; Barbara Shacklett; Eric A Cohen; Maged P Ghali; Jean-Pierre Routy; Petronela Ancuta
Journal:  AIDS       Date:  2019-07-01       Impact factor: 4.177

8.  Viral Characteristics Associated with Maintenance of Elite Neutralizing Activity in Chronically HIV-1 Clade C-Infected Monozygotic Pediatric Twins.

Authors:  Nitesh Mishra; Muzamil Ashraf Makhdoomi; Shaifali Sharma; Sanjeev Kumar; Ayushman Dobhal; Deepshikha Kumar; Himanshi Chawla; Ravinder Singh; Uma Kanga; Bimal Kumar Das; Rakesh Lodha; Sushil K Kabra; Kalpana Luthra
Journal:  J Virol       Date:  2019-08-13       Impact factor: 5.103

9.  Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques.

Authors:  Chie Sugimoto; Kristen M Merino; Atsuhiko Hasegawa; Xiaolei Wang; Xavier A Alvarez; Hiroshi Wakao; Kazuyasu Mori; Woong-Ki Kim; Ronald S Veazey; Elizabeth S Didier; Marcelo J Kuroda
Journal:  J Virol       Date:  2017-08-10       Impact factor: 5.103

10.  Impaired Development and Expansion of Germinal Center Follicular Th Cells in Simian Immunodeficiency Virus-Infected Neonatal Macaques.

Authors:  Huanbin Xu; Widade Ziani; Jiasheng Shao; Lara A Doyle-Meyers; Kasi E Russell-Lodrigue; Marion S Ratterree; Ronald S Veazey; Xiaolei Wang
Journal:  J Immunol       Date:  2018-08-13       Impact factor: 5.422
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