Sana Alibi1, Dámaso Crespo2, Jesús Navas2,3. 1. Analysis and Process Applied to the Environment UR17ES32, Higher Institute of Applied Sciences and Technology, Mahdia 5121, Tunisia. 2. BIOMEDAGE Group, Faculty of Medicine, Cantabria University, 39011 Santander, Spain. 3. Instituto de Investigación Valdecilla (IDIVAL), 39011 Santander, Spain.
Abstract
The vegetal world constitutes the main factory of chemical products, in particular secondary metabolites like phenols, phenolic acids, terpenoids, and alkaloids. Many of these compounds are small molecules with antibacterial activity, although very few are actually in the market as antibiotics for clinical practice or as food preservers. The path from the detection of antibacterial activity in a plant extract to the practical application of the active(s) compound(s) is long, and goes through their identification, purification, in vitro and in vivo analysis of their biological and pharmacological properties, and validation in clinical trials. This review presents an update of the main contributions published on the subject, focusing on the compounds that showed activity against multidrug-resistant relevant bacterial human pathogens, paying attention to their mechanisms of action and synergism with classical antibiotics.
The vegetal world constitutes the main factory of chemical products, in particular sn class="Chemical">econdary metabolites like phenols, phenolic acids, terpenoids, and alkaloids. Many of these compounds are small molecules with antibacterial activity, although very few are actually in the market as antibiotics for clinical practice or as food preservers. The path from the detection of antibacterial activity in a plant extract to the practical application of the active(s) compound(s) is long, and goes through their identification, purification, in vitro and in vivo analysis of their biological and pharmacological properties, and validation in clinical trials. This review presents an update of the main contributions published on the subject, focusing on the compounds that showed activity against multidrug-resistant relevant bacterial human pathogens, paying attention to their mechanisms of action and synergism with classical antibiotics.
Entities:
Keywords:
antibacterial activity; multi-drug resistance; plant-derivates; small molecules
Authors: Bruno Casciaro; Laura Mangiardi; Floriana Cappiello; Isabella Romeo; Maria Rosa Loffredo; Antonia Iazzetti; Andrea Calcaterra; Antonella Goggiamani; Francesca Ghirga; Maria Luisa Mangoni; Bruno Botta; Deborah Quaglio Journal: Molecules Date: 2020-08-09 Impact factor: 4.411