Literature DB >> 33667360

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate.

Ram Prosad Chakrabarty1, Navdeep S Chandel2.   

Abstract

Recent evidence supports the notion that mitochondrial metabolism is necessary for the determination of stem cell fate. Historically, mitochondrial metabolism is linked to the production of ATP and tricarboxylic acid (TCA) cycle metabolites to support stem cell survival and growth, respectively. However, it is now clear that beyond these canonical roles, mitochondria as signaling organelles dictate stem cell fate and function. In this review, we focus on key conceptual ideas on how mitochondria control mammalian stem cell fate and function through reactive oxygen species (ROS) generation, TCA cycle metabolite production, NAD+/NADH ratio regulation, pyruvate metabolism, and mitochondrial dynamics.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  L-2-HG; ROS; TCA cycle; acetyl-CoA; epigenetics; mitochondrial dynamics; pyruvate

Mesh：

Year:  2021        PMID： 33667360      PMCID： PMC7944920          DOI： 10.1016/j.stem.2021.02.011

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  141 in total

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Journal:  Nature       Date:  2017-03-08       Impact factor: 49.962

3.  Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.

Authors:  Keiyo Takubo; Go Nagamatsu; Chiharu I Kobayashi; Ayako Nakamura-Ishizu; Hiroshi Kobayashi; Eiji Ikeda; Nobuhito Goda; Yasmeen Rahimi; Randall S Johnson; Tomoyoshi Soga; Atsushi Hirao; Makoto Suematsu; Toshio Suda
Journal:  Cell Stem Cell       Date:  2013-01-03       Impact factor: 24.633

Review 4.  Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

Authors:  Navdeep S Chandel; Heinrich Jasper; Theodore T Ho; Emmanuelle Passegué
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Review 5.  The Chemistry and Biology of Ferroptosis.

Authors:  Brent R Stockwell; Xuejun Jiang
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6.  An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate.

Authors:  Maria Maryanovich; Yehudit Zaltsman; Antonella Ruggiero; Andres Goldman; Liat Shachnai; Smadar Levin Zaidman; Ziv Porat; Karin Golan; Tsvee Lapidot; Atan Gross
Journal:  Nat Commun       Date:  2015-07-29       Impact factor: 14.919

7.  O2 regulates stem cells through Wnt/β-catenin signalling.

Authors:  Jolly Mazumdar; W Timothy O'Brien; Randall S Johnson; Joseph C LaManna; Juan C Chavez; Peter S Klein; M Celeste Simon
Journal:  Nat Cell Biol       Date:  2010-09-19       Impact factor: 28.824

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Authors:  Theodore T Ho; Matthew R Warr; Emmalee R Adelman; Olivia M Lansinger; Johanna Flach; Evgenia V Verovskaya; Maria E Figueroa; Emmanuelle Passegué
Journal:  Nature       Date:  2017-03-01       Impact factor: 49.962

9.  TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation.

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Journal:  Cell Metab       Date:  2015-07-23       Impact factor: 31.373
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  22 in total

Review 1.  Mitochondrial regulation during male germ cell development.

Authors:  Xiaoli Wang; Lisha Yin; Yujiao Wen; Shuiqiao Yuan
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Review 2.  Regulation of energy metabolism in human pluripotent stem cells.

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5.  Beyond ATP, new roles of mitochondria.

Authors:  Ram Prosad Chakrabarty; Navdeep S Chandel
Journal:  Biochem (Lond)       Date:  2022-08-23

6.  Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma.

Authors:  E John Tokarsky; Jesse C Crow; Lillian M Guenther; John Sherman; Cenny Taslim; Gabriela Alexe; Kathleen I Pishas; Galen Rask; Blake S Justis; Ana Kasumova; Kimberly Stegmaier; Stephen L Lessnick; Emily R Theisen
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7.  SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes.

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Review 8.  Amino Acid Transport and Metabolism Regulate Early Embryo Development: Species Differences, Clinical Significance, and Evolutionary Implications.

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9.  Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo.

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10.  Mitochondria transplantation between living cells.

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