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Literature DB >> 33665066

First case of Kluyveromyces marxianus (Candida kefyr) late onset keratitis after lamellar endothelial corneal graft.

Alexander M Aldejohann¹, Johanna Theuersbacher², Lukas Haug³, Olga S Lamm², Grit Walther⁴, Oliver Kurzai^1,4, Jost Hillenkamp², Daniel Kampik².

Abstract

We present a case of Kluyveromyces marxianus keratitis nine months after Descement's membrane endothelial keratoplasty (DMEK) in a patient with Fuchs endothelial disease. Endothelial scraping revealed this rare yeast infection at the interface between graft and host cornea. Immediate antifungal treatment with intracameral and corneal intrastromal injections of voriconazole and amphotericin B remained unsuccessful, requiring penetrating keratoplasty. This case highlights the challenging management of keratomycosis in patients with endothelial grafts.

Entities: Chemical Disease Species

Keywords: Amphotericin B; Corneal transplantation; DMEK; Fungal keratits; Kluyveromyces marxianus (Candida kefyr); Voriconazole

Year: 2021 PMID： 33665066 PMCID： PMC7902762 DOI： 10.1016/j.mmcr.2021.02.001

Source DB: PubMed Journal: Med Mycol Case Rep ISSN： 2211-7539

20 in total

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Authors: Wei-Boon Khor; Venkatesh N Prajna; Prashant Garg; Jodhbir S Mehta; Lixin Xie; Zuguo Liu; Ma Dominga B Padilla; Choun-Ki Joo; Yoshitsugu Inoue; Panida Goseyarakwong; Fung-Rong Hu; Kohji Nishida; Shigeru Kinoshita; Vilavun Puangsricharern; Ai-Ling Tan; Roger Beuerman; Alvin Young; Namrata Sharma; Benjamin Haaland; Francis S Mah; Elmer Y Tu; Fiona J Stapleton; Richard L Abbott; Donald Tiang-Hwee Tan
Journal: Am J Ophthalmol Date: 2018-08-09 Impact factor: 5.258

2. Incidence and Clinical Course of Immune Reactions after Descemet Membrane Endothelial Keratoplasty: Retrospective Analysis of 1000 Consecutive Eyes.

Authors: Deniz Hos; Onur Tuac; Friederike Schaub; Tisha P Stanzel; Silvia Schrittenlocher; Martin Hellmich; Björn O Bachmann; Claus Cursiefen
Journal: Ophthalmology Date: 2017-01-13 Impact factor: 12.079

3. Evolving Techniques in Corneal Transplantation.

Authors: Grace E Boynton; Maria A Woodward
Journal: Curr Surg Rep Date: 2015-02-01

4. Fusarium Keratitis in Germany.

Authors: Grit Walther; Serena Stasch; Kerstin Kaerger; Axel Hamprecht; Mathias Roth; Oliver A Cornely; Gerd Geerling; Colin R Mackenzie; Oliver Kurzai; Marie von Lilienfeld-Toal
Journal: J Clin Microbiol Date: 2017-07-26 Impact factor: 5.948

5. Role of opportunistic fungi in ocular infections in Nigeria.

Authors: H C Gugnani; S Gupta; R S Talwar
Journal: Mycopathologia Date: 1978-12-18 Impact factor: 2.574

6. Intrastromal antifungal injection with secondary lamellar interface infusion for late-onset infectious keratitis after DSAEK.

Authors: Elmer Y Tu; Joshua Hou
Journal: Cornea Date: 2014-09 Impact factor: 2.651

First case of Kluyveromyces marxianus (Candida kefyr) late onset keratitis after lamellar endothelial corneal graft.

1. The Asia Cornea Society Infectious Keratitis Study: A Prospective Multicenter Study of Infectious Keratitis in Asia.

2. Incidence and Clinical Course of Immune Reactions after Descemet Membrane Endothelial Keratoplasty: Retrospective Analysis of 1000 Consecutive Eyes.

3. Evolving Techniques in Corneal Transplantation.

4. Fusarium Keratitis in Germany.

5. Role of opportunistic fungi in ocular infections in Nigeria.

6. Intrastromal antifungal injection with secondary lamellar interface infusion for late-onset infectious keratitis after DSAEK.

7. Epidemiology of Candida kefyr in patients with hematologic malignancies.

8. Pharmacokinetics of intracameral voriconazole injection.

9. Late-onset fungal interface keratitis following endothelial keratoplasty with positive donor fungal culture.

10. Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002-2010).