Tao Cheng1,2,3, Bo-Fu Liu1,2,3, Tian-Yong Han1, Zhi-Han Gu1,2,3, Pan Pan1,2, Haifang Yu1,2,3. 1. Emergency Department. 2. Laboratory of Emergency Medicine, West China Hospital, Sichuan University. 3. Disaster Medical Center, Sichuan University, Chengdu, Sichuan, China.
Abstract
BACKGROUND: Previous studies have showed that anti-acid therapy with proton pump inhibitors (PPIs) can inhibit pancreatic secretion and it may be used in treating acute pancreatitis (AP). But at present, there is no systematic reviews for the evidence and the therapeutic effectiveness and safety of anti-acid therapy with PPIs in AP were not unclear. Therefore, we will undertake a systematic review of the literature to summarize previous evidence regarding this topic, in order to clarify the effectiveness and safety of anti-acid therapy with PPIs in AP. METHODS: We will search the EMBASE, WANFANG DATA, Web of Knowledge, China National Knowledge Infrastructure, PubMed, ClinicalTrials.gov and Cochrane Library from inception to June 30,2021 to retrieve relevant studies using the search strategy: ("Proton pump inhibitors" OR "PPI" OR "PPIs" OR "Omeprazole" OR "Tenatoprazole" OR "Pantoprazole" OR "acid suppression therapy" OR "acid suppression drugs") AND ("pancreatitis" OR "pancreatitides"). Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I2 statistic. RESULTS: This study assessed the efficiency and safety of proton pump inhibitors for treating acute pancreatitis. CONCLUSIONS: This study will provide reliable evidence-based evidence for the clinical application of PPIs for treating AP. ETHICS AND DISSEMINATION: Ethical approval is unnecessary as this protocol is only for systematic review and does not involve privacy data. The findings of this study will be disseminated electronically through a peer-review publication or presented at a relevant conference.
BACKGROUND: Previous studies have showed that anti-acid therapy with proton pump inhibitors (PPIs) can inhibit pancreatic secretion and it may be used in treating acute pancreatitis (AP). But at present, there is no systematic reviews for the evidence and the therapeutic effectiveness and safety of anti-acid therapy with PPIs in AP were not unclear. Therefore, we will undertake a systematic review of the literature to summarize previous evidence regarding this topic, in order to clarify the effectiveness and safety of anti-acid therapy with PPIs in AP. METHODS: We will search the EMBASE, WANFANG DATA, Web of Knowledge, China National Knowledge Infrastructure, PubMed, ClinicalTrials.gov and Cochrane Library from inception to June 30,2021 to retrieve relevant studies using the search strategy: ("Proton pump inhibitors" OR "PPI" OR "PPIs" OR "Omeprazole" OR "Tenatoprazole" OR "Pantoprazole" OR "acid suppression therapy" OR "acid suppression drugs") AND ("pancreatitis" OR "pancreatitides"). Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I2 statistic. RESULTS: This study assessed the efficiency and safety of proton pump inhibitors for treating acute pancreatitis. CONCLUSIONS: This study will provide reliable evidence-based evidence for the clinical application of PPIs for treating AP. ETHICS AND DISSEMINATION: Ethical approval is unnecessary as this protocol is only for systematic review and does not involve privacy data. The findings of this study will be disseminated electronically through a peer-review publication or presented at a relevant conference.
Authors: Penny F Whiting; Anne W S Rutjes; Marie E Westwood; Susan Mallett; Jonathan J Deeks; Johannes B Reitsma; Mariska M G Leeflang; Jonathan A C Sterne; Patrick M M Bossuyt Journal: Ann Intern Med Date: 2011-10-18 Impact factor: 25.391
Authors: Nelli Farkas; Lilla Hanák; Alexandra Mikó; Judit Bajor; Patrícia Sarlós; József Czimmer; Áron Vincze; Szilárd Gódi; Dániel Pécsi; Péter Varjú; Katalin Márta; Péter Jenő Hegyi; Bálint Erőss; Zsolt Szakács; Tamás Takács; László Czakó; Balázs Németh; Dóra Illés; Balázs Kui; Erika Darvasi; Ferenc Izbéki; Adrienn Halász; Veronika Dunás-Varga; László Gajdán; József Hamvas; Mária Papp; Ildikó Földi; Krisztina Eszter Fehér; Márta Varga; Klára Csefkó; Imola Török; Farkas Hunor-Pál; Artautas Mickevicius; Elena Ramirez Maldonado; Ville Sallinen; János Novák; Ali Tüzün Ince; Shamil Galeev; Barnabás Bod; János Sümegi; Petr Pencik; Attila Szepes; Andrea Szentesi; Andrea Párniczky; Péter Hegyi Journal: Front Physiol Date: 2019-09-04 Impact factor: 4.566