Cheng Huang1, Qiong Wang2, Qin Zhang3, Biao Zhou4, Jun Lin3, Hua Meng5. 1. Department of Orthopedics, China-Japan Friendship Hospital, Beijing, China. 2. Department of Nephrology, Beijing Hospital, Beijing, China. 3. Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China. 4. Department of General Surgery, China-Japan Friendship Hospital, Beijing, China. 5. Department of General Surgery, China-Japan Friendship Hospital, Beijing, China, menghuade@hotmail.com.
Abstract
BACKGROUND: While bariatric surgery could result in weight loss as well as glycaemia improvement, the short-term impact on bone health in a high glycemic environment following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) remains intriguing. OBJECTIVE: The aim of this study was to compare the short-term effects of RYGB and SG procedures on bone health in Zucker diabetic fatty (ZDFfa/fa) rats. METHODS: Thirty age-matched male ZDFfa/fa rats were randomized into RYGB, SG, and sham groups after establishment of the diabetic model. Body weight, blood glucose, bone mineral density (BMD), the level of bone turnover markers (BTM), vitamin D, and serum calcium and phosphorus were measured 4 weeks after the operation. RESULTS: The RYGB procedure brought about lower blood glucose, BMD, serum calcium and phosphorus levels, as well as a relatively higher bone turnover rate and 1,25(OH)2VD level, compared to the SG and sham groups, while the influences of the SG procedure were not significant. 25(OH)VD demonstrated no significant difference among the 3 groups. CONCLUSIONS: Despite its excellent ability to provide short-term glycemic control, the RYGB procedure could led to more severe impairment of bone health compared to the SG procedure. Bone health should be procured after bariatric surgery, especially with the RYGB procedure. Early detection of BMD and BTM may help to avoid deterioration of bone.
BACKGROUND: While bariatric surgery could result in weight loss as well as glycaemia improvement, the short-term impact on bone health in a high glycemic environment following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) remains intriguing. OBJECTIVE: The aim of this study was to compare the short-term effects of RYGB and SG procedures on bone health in Zucker diabetic fatty (ZDFfa/fa) rats. METHODS: Thirty age-matched male ZDFfa/fa rats were randomized into RYGB, SG, and sham groups after establishment of the diabetic model. Body weight, blood glucose, bone mineral density (BMD), the level of bone turnover markers (BTM), vitamin D, and serum calcium and phosphorus were measured 4 weeks after the operation. RESULTS: The RYGB procedure brought about lower blood glucose, BMD, serum calcium and phosphorus levels, as well as a relatively higher bone turnover rate and 1,25(OH)2VD level, compared to the SG and sham groups, while the influences of the SG procedure were not significant. 25(OH)VD demonstrated no significant difference among the 3 groups. CONCLUSIONS: Despite its excellent ability to provide short-term glycemic control, the RYGB procedure could led to more severe impairment of bone health compared to the SG procedure. Bone health should be procured after bariatric surgery, especially with the RYGB procedure. Early detection of BMD and BTM may help to avoid deterioration of bone.
Authors: J Cornish; K E Callon; U Bava; C Lin; D Naot; B L Hill; A B Grey; N Broom; D E Myers; G C Nicholson; I R Reid Journal: J Endocrinol Date: 2002-11 Impact factor: 4.286
Authors: Michael M Meguid; Eduardo J B Ramos; Susumu Suzuki; Yuan Xu; Zachariah M George; Undurti N Das; Karen Hughes; Robert Quinn; Chung Chen; William Marx; Paul R G Cunningham Journal: J Gastrointest Surg Date: 2004 Jul-Aug Impact factor: 3.452