Literature DB >> 33652925

Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids.

Jana Maříková1, Abdullah Al Mamun2, Latifah Al Shammari2, Jan Korábečný3,4, Tomáš Kučera3, Daniela Hulcová2,5, Jiří Kuneš1, Milan Malaník6, Michaela Vašková7, Eliška Kohelová2, Lucie Nováková8, Lucie Cahlíková2, Milan Pour1.   

Abstract

Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum × hybridum cv. Ferrari and Narcissus pseudonarcissus cv. Carlton. The chemical structures were identified by various spectroscopic (one- and two-dimensional (1D and 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) and by comparison with literature data of similar compounds. Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabduliine (2), showed balanced inhibition potency for both studied enzymes, with IC50 values of 3.29 ± 0.73 µM for hAChE and 3.44 ± 0.02 µM for hBuChE. The accommodation of 2 into the active sites of respective enzymes was predicted using molecular modeling simulation.

Entities:  

Keywords:  9-O-demethyllycorenine; Alzheimer’s disease; Amaryllidaceae; narciabduliine

Mesh：

Substances：

Year:  2021        PMID： 33652925      PMCID： PMC7956344          DOI： 10.3390/molecules26051279

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


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