| Literature DB >> 31261031 |
Daniela Hulcová1, Jana Maříková2, Jan Korábečný3, Anna Hošťálková4, Daniel Jun5, Jiří Kuneš2, Jakub Chlebek4, Lubomír Opletal4, Angela De Simone6, Lucie Nováková7, Vincenza Andrisano6, Aleš Růžička8, Lucie Cahlíková9.
Abstract
Twenty-one known Amaryllidaceae alkaloids of various structural types and one undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of Narcissus pseudonarcissus L. cv. Dutch Master. The chemical structures were elucidated by combination of MS, HRMS, 1D and 2D NMR spectroscopic techniques, and by comparison with literature data. Narcimatuline amalgamates two basic scaffolds of Amaryllidaceae alkaloids in its core, namely galanthamine and galanthindole. All isolated compounds were evaluated for their in vitro acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), prolyl oligopeptidase (POP), and glycogen synthase kinase-3β (GSK-3β) inhibitory activities. The most interesting biological profile was demonstrated by newly isolated alkaloid narcimatuline.Entities:
Keywords: Alkaloids; Alzheimer's disease; Amaryllidaceae; Cholinesterase inhibition; Glycogen synthase kinase-3β inhibition; Narcimatuline; Narcissus pseudonarcissus L. cv. Dutch master; Prolyl oligopeptidase
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Year: 2019 PMID： 31261031 DOI： 10.1016/j.phytochem.2019.112055
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072