| Literature DB >> 33651237 |
Miriam Becke1, Lara Tucha2,3, Matthias Weisbrod4,5, Steffen Aschenbrenner6, Oliver Tucha2,3, Anselm B M Fuermaier2.
Abstract
As attention-deficit/hyperactivity disorder (ADHD) is a feasible target for individuals aiming to procure stimulant medication or accommodations, there is a high clinical need for accurate assessment of adult ADHD. Proven falsifiability of commonly used diagnostic instruments is therefore of concern. The present study aimed to develop a new, ADHD-specific infrequency index to aid the detection of non-credible self-report. Disorder-specific adaptations of four detection strategies were embedded into the Conners' Adult ADHD Rating Scales (CAARS) and tested for infrequency among credible neurotypical controls (n = 1001) and credible adults with ADHD (n = 100). The new index' ability to detect instructed simulators (n = 242) and non-credible adults with ADHD (n = 22) was subsequently examined using ROC analyses. Applying a conservative cut-off score, the new index identified 30% of participants instructed to simulate ADHD while retaining a specificity of 98%. Items assessing supposed symptoms of ADHD proved most useful in distinguishing genuine patients with ADHD from simulators, whereas inquiries into unusual symptom combinations produced a small effect. The CAARS Infrequency Index (CII) outperformed the new infrequency index in terms of sensitivity (46%), but not overall classification accuracy as determined in ROC analyses. Neither the new infrequency index nor the CII detected non-credible adults diagnosed with ADHD with adequate accuracy. In contrast, both infrequency indices showed high classification accuracy when used to detect symptom over-report. Findings support the new indices' utility as an adjunct measure in uncovering feigned ADHD, while underscoring the need to differentiate general over-reporting from specific forms of feigning.Entities:
Keywords: Attention-deficit hyperactivity disorder; Conners’ adult ADHD rating scales; Feigning; Non-credible symptom report; Symptom validity
Mesh:
Substances:
Year: 2021 PMID: 33651237 PMCID: PMC8295107 DOI: 10.1007/s00702-021-02318-y
Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN: 0300-9564 Impact factor: 3.850
Descriptive data by group
| Neurotypical Control Group | ADHD Group | Simulation Group | |||
|---|---|---|---|---|---|
| Credible | Overreporting | Credible | Non-Credible | ||
| 1001 | 18 | 100 | 22 | 242 | |
| Total | 1019 | 122 | |||
| Age (years) | |||||
| Median (MAD) | 49 (11) | 32 (4) | 34 (9) | 31.50 (10.5) | 20 (1) |
| Range | 40 | 33 | 62 | 42 | 42 |
| Sex (m/f) | 494/504 | 13/5 | 46/54 | 13/9 | 64/178 |
| % | 49.4/50.3* | 72.2/27.8 | 46.0/54.0 | 59.1/40.9 | 26.4/73.6 |
| Education | |||||
| Years | |||||
| Median (MAD) | 13 (3) | 13 (3) | 13 (3) | 14 (2) | 13 (1) |
| Range | 10 | 10 | 16 | 15 | 15 |
| ADHD symptomatology | |||||
| Pasta | |||||
| Median (MAD) | 40.0 (10) | 40.5 (14.5) | 14.0 (7) | ||
| Range | 70 | 53.5 | 56 | ||
| Presentb | |||||
| Median (MAD) | 31.0 (6) | 28.5 (5.5) | 11.0 (5) | ||
| Range | 53 | 40 | 45 | ||
MAD median absolute deviation
aWender Utah Rating Scale
bADHD Self-Report Scale
*Three participants did not disclose their gender
Fig. 1Endorsement of New Items by Participants in the Neurotypical Control Group and ADHD Group. Note. Bars illustrate the percentage of participants who endorsed the new items (i.e., who marked response options “2” or “3”). Herein, credible participants from the Neurotypical Control Group and ADHD Group were combined into one sample. Items marked with an asterisk form the ADHD Credibility Index
Summary Statistics for ADHD Credibility Index (ACI) Scores by Group
| Neurotypical Control Group | ADHD Group | Simulation Group | |||
|---|---|---|---|---|---|
| Credible | Overreporting | Credible | Non-Credible | ||
| Median (MAD) | 2 (2) | 22 (5) | 11 (4) | 10.5 (5.5) | 17 (7) |
| ACI-A | 0 (0) | 5 (1) | 2 (1) | 2.5 (1.5) | 4 (2) |
| ACI-B | 0 (0) | 5.5 (1.5) | 3 (1) | 2 (1) | 4 (2) |
| ACI-C | 0 (0) | 6 (1) | 3 (1) | 2 (1) | 4 (2) |
| ACI-D | 0 (0) | 6 (1.5) | 2 (1) | 2 (2) | 4 (2) |
| Range | 25 | 23 | 32 | 17 | 36 |
| Min—Max | 0–25 | 7–30 | 0–32 | 2–19 | 0–36 |
| Mode | 0 | 24 | 5a | 5 | 19 |
| ACI-A | 0 | 5 | 2 | 1 | 5 |
| ACI-B | 0 | 5.5 | 3 | 1 | 6 |
| ACI-C | 0 | 6 | 2 | 2 | 5 |
| ACI-D | 0 | 6 | 3 | 2 | 5 |
MAD median absolute deviation, ACI-A supposed symptoms subscale, ACI-B exaggerated symptoms subscale, ACI-C symptom combinations subscale, ACI-D selectivity subscale
aMultiple modes exist. The smallest value is shown here
ADHD Credibility Index Scores needed to ensure at least 90% specificity
| Age Group (years) | Group | Total | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cut-Off Score | % below | Cut-Off Score | % below | Cut-Off Score | % below | |||||
| Total | Control + ADHD | 1095 | 11 | 91.10 | 537 | 12 | 92.40 | 555 | 9 | 90.50 |
| Control Group | 1000 | 8 | 91.70 | 493 | 9 | 90.70 | 504 | 7 | 91.50 | |
| ADHD Group | 95 | 21 | 94.70 | 44 | 21 | 95.50 | 51 | 20 | 90.20 | |
| 18–29 | Control + ADHD | 141 | 13 | 91.50 | 53 | 16 | 92.50 | 87 | 12 | 92.00 |
| Control Group | 109 | 12 | 92.70 | 36 | 15 | 91.70 | 72 | 8 | 93.10 | |
| ADHD Group | 32 | 17 | 93.80 | 17 | 17 | 94.10 | 15 | 17 | 93.30 | |
| 30–39 | Control + ADHD | 221 | 16 | 90.00 | 92 | 17 | 91.30 | 129 | 14 | 90.70 |
| Control Group | 191 | 12 | 90.60 | 80 | 16 | 90.00 | 111 | 8 | 91.00 | |
| ADHD Group | 30 | 21 | 93.30 | 12 | 21 | 100.0 | 18 | 23 | 94.40 | |
| 40–49 | Control + ADHD | 244 | 11 | 90.20 | 116 | 12 | 93.10 | 127 | 10 | 90.60 |
| Control Group | 228 | 9 | 90.80 | 111 | 11 | 91.00 | 116 | 6 | 90.50 | |
| ADHD Group | 16 | 18 | 93.80 | 5 | 13 | 100.0 | 12 | 18 | 90.90 | |
| 50 + | Control + ADHD | 487 | 6 | 91.80 | 274 | 6 | 91.20 | 212 | 6 | 92.50 |
| Control Group | 470 | 5 | 91.90 | 264 | 5 | 91.70 | 205 | 5 | 92.20 | |
| ADHD Group | 17 | 27 | 94.10 | 10 | 27 | 100.0 | 7 | 22 | 100.0 | |
Data shown here are based on credible participants’ responses only
Association of ADHD symptomatology and ADHD Credibility Index (ACI) Scores
| Scale | Group | Classification | % | ACI | |
|---|---|---|---|---|---|
| % Not Suspect | % Suspect | ||||
| CAARS DSM Inattention (E) | Control Group | No scale elevation | 94.18 | 100.00 | 0.00 |
| Symptomatic | 4.15 | 92.86 | 7.14 | ||
| ADHD Group | No scale elevation | 9.47 | 100.00 | 0.00 | |
| Symptomatic | 43.16 | 100.00 | 0.00 | ||
| Total | No scale elevation | 86.91 | 100.00 | 0.00 | |
| Symptomatic | 7.49 | 96.39 | 3.61 | ||
| CAARS DSM Hyperactivity (F) | Control Group | No scale elevation | 96.05 | 99.90 | 0.10 |
| Symptomatic | 3.55 | 77.78 | 22.22 | ||
| ADHD Group | No scale elevation | 56.84 | 100.00 | 0.00 | |
| Symptomatic | 32.63 | 93.55 | 6.45 | ||
| Total | No scale elevation | 92.69 | 99.90 | 0.10 | |
| Symptomatic | 6.05 | 85.07 | 14.93 | ||
| CAARS DSM Total (G) | Control Group | No scale elevation | 95.16 | 100.00 | 0.00 |
| Symptomatic | 3.65 | 91.89 | 8.11 | ||
| ADHD Group | No scale elevation | 26.32 | 100.00 | 0.00 | |
| Symptomatic | 40.00 | 100.00 | 0.00 | ||
| Total | No scale elevation | 89.26 | 100.00 | 0.00 | |
| Symptomatic | 6.77 | 96.00 | 4.00 | ||
| CAARS ADHD Index (H) | Control Group | No scale elevation | 97.24 | 99.90 | 0.10 |
| Symptomatic | 2.47 | 64.00 | 36.00 | ||
| ADHD Group | No scale elevation | 29.47 | 100.00 | 0.00 | |
| Symptomatic | 55.79 | 100.00 | 0.00 | ||
| Total | No scale elevation | 91.43 | 99.90 | 0.10 | |
| Symptomatic | 7.04 | 88.46 | 11.54 | ||
Classifications are based on the CAARS DSM Scale T-Scores: ‘No Scale Elevation’ if T < 65, ‘Symptomatic’ if T ≥ 65. Percentages in the ‘%’ column do not add up to 100 as overreporting participants (T ≥ 80) are not reported here
Sensitivity, Specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of the ADHD Credibility Index (ACI) and CAARS Infrequency Index (CII) in the Detection of Simulated ADHD, Non-Credible Adults with ADHD, and Overreport on CAARS DSM Scales
| Base Rate | Group | |||
|---|---|---|---|---|
| Simulation | Non-Credible ADHD | Overreport | ||
| ACI | ||||
| Sensitivity | 30.34% | 0.0% | 38.34% | |
| Specificity | 98.50% | 94.74% | 98.81% | |
| PPV | 10 | 69.20% | 0.0% | 78.13% |
| 20 | 83.49% | 0.0% | 88.94% | |
| 30 | 89.66% | 0.0% | 93.23% | |
| 50 | 95.29% | 0.0% | 96.98% | |
| NPV | 10 | 92.71% | 89.50% | 93.52% |
| 20 | 84.98% | 79.12% | 86.50% | |
| 30 | 76.74% | 68.85% | 78.90% | |
| 50 | 58.58% | 48.65% | 61.58% | |
| CII | ||||
| Sensitivity | 46.28% | 27.27% | 64.53% | |
| Specificity | 95.09% | 69.00% | 96.86% | |
| PPV | 10 | 51.17% | 8.90% | 69.57% |
| 20 | 70.22% | 18.03% | 83.73% | |
| 30 | 80.16% | 27.38% | 89.82% | |
| 50 | 90.41% | 46.80% | 95.37% | |
| NPV | 10 | 94.09% | 89.52% | 96.09% |
| 20 | 87.62% | 79.14% | 91.61% | |
| 30 | 80.51% | 68.88% | 86.44% | |
| 50 | 63.90% | 48.69% | 73.20% | |
Participants were classified as Overreporters if their T-scores on any CAARS DSM Scale were ≧ 80
Results of ROC analyses distinguishing credible adults with ADHD (n = 95) from simulators (n = 234)
| AUC | SE | 95% CI | |||
|---|---|---|---|---|---|
| Lower | Upper | ||||
| ACI | 0.651 | 0.030 | < 0.01* | 0.591 | 0.710 |
| CAARS DSM Inattention (E) | 0.410 | 0.031 | 0.011* | 0.349 | 0.472 |
| CAARS DSM Hyperactivity/Impulsivity (F) | 0.623 | 0.031 | < 0.01* | 0.561 | 0.684 |
| CAARS DSM Total (G) | 0.538 | 0.031 | 0.282 | 0.476 | 0.600 |
| CII | 0.527 | 0.032 | 0.435 | 0.465 | 0.590 |
AUC area under the curve, ACI ADHD Credibility Index, CII Conners’ Infrequency Index
*Statistically significant at α = 0.05
Fig. 2Receiver operating characteristics (ROC) curve indicating diagnostic accuracy of the ADHD Credibility Index (ACI), the CAARS DSM Scales, and the CAARS Infrequency Index (CII) in identifying feigned ADHD (Simulation Group, n = 234) relative to ADHD (ADHD Group, n = 95)
Results of ROC analyses distinguishing credible adults with ADHD (n = 95) from non-credible adults with ADHD (n = 20)
| AUC | SE | 95% CI | |||
|---|---|---|---|---|---|
| Lower | Upper | ||||
| ACI | 0.462 | 0.075 | 0.598 | 0.315 | 0.609 |
| CAARS DSM Inattention (E) | 0.517 | 0.081 | 0.808 | 0.358 | 0.676 |
| CAARS DSM Hyperactivity/Impulsivity (F) | 0.442 | 0.069 | 0.417 | 0.307 | 0.577 |
| CAARS DSM Total (G) | 0.446 | 0.078 | 0.445 | 0.293 | 0.598 |
| CII | 0.457 | 0.075 | 0.548 | 0.311 | 0.603 |
AUC area under the curve, ACI ADHD Credibility Index, CII Conners’ Infrequency Index
Fig. 3Receiver operating characteristics (ROC) curve illustrating diagnostic accuracy of the ADHD Credibility Index (ACI), the CAARS DSM Scales, and the CAARS Infrequency Index (CII) in discriminating non-credible adults with ADHD (non-credible ADHD Group, n = 20) from credible adults with ADHD (credible ADHD Group, n = 95)
Results of ROC analyses distinguishing participants with unremarkable T-scores on the DSM scales (n = 1174) from over-reporters (n = 193)
| Overreport on | AUC | SE | 95%- | |||
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| ACI | Any CAARS DSM Scale | 0.941 | 0.007 | < 0.01* | 0.928 | 0.954 |
| CAARS DSM Inattention (E) | 0.928 | 0.008 | < 0.01* | 0.913 | 0.944 | |
| CAARS DSM Hyperactivity (F) | 0.959 | 0.007 | < 0.01* | 0.946 | 0.972 | |
| CAARS DSM Total (G) | 0.952 | 0.006 | < 0.01* | 0.940 | 0.964 | |
| CII | Any CAARS DSM Scale | 0.966 | 0.005 | < 0.01* | 0.957 | 0.975 |
| CAARS DSM Inattention (E) | 0.958 | 0.006 | < 0.01* | 0.947 | 0.969 | |
| CAARS DSM Hyperactivity (F) | 0.978 | 0.004 | < 0.01* | 0.971 | 0.986 | |
| CAARS DSM Total (G) | 0.970 | 0.004 | < 0.01* | 0.962 | 0.979 | |
AUC area under the curve, ACI ADHD Credibility Index, CII Conners’ Infrequency Index
*Statistically significant at α = 0.05
Fig. 4Receiver operating characteristics (ROC) curve indicating diagnostic accuracy of the ADHD Credibility Index (ACI) and the CAARS Infrequency Index (CII) in distinguishing over-reporters (i.e., participants from any group who presented with T-Scores ≥ 80 on any DSM Sale, n = 193) from participants who scored in the unremarkable range on all DSM Scales (n = 1174)
Agreement between ADHD Credibility Index and Overreport on CAARS DSM Scales
| Scale | Group | % | ADHD Credibility Index | |
|---|---|---|---|---|
| Not Suspect (%) | Suspect (%) | |||
| CAARS DSM Inattention (E) | Control Group | 1.68 | 47.06 | 52.94 |
| ADHD Group | 47.37 | 88.89 | 11.11 | |
| Simulation Group | 42.74 | 47.00 | 53.00 | |
| Non-Credible ADHD Group | 50.00 | 100.00 | 0.00 | |
| Total | 12.63 | 61.05 | 38.95 | |
| CAARS DSM Hyperactivity/Impulsivity (F) | Control Group | 0.39 | 25.00 | 75.00 |
| ADHD Group | 10.53 | 70.00 | 30.00 | |
| Simulation Group | 32.05 | 38.67 | 61.33 | |
| Non-Credible ADHD Group | 5.00 | 100.00 | 0.00 | |
| Total | 6.61 | 42.22 | 57.78 | |
| CAARS DSM Total (G) | Control Group | 1.18 | 25.00 | 75.00 |
| ADHD Group | 33.68 | 84.38 | 15.62 | |
| Simulation Group | 47.44 | 46.85 | 53.15 | |
| Non-Credible ADHD Group | 35.00 | 100.00 | 0.00 | |
| Total | 11.89 | 54.94 | 45.06 | |
| CAARS ADHD Index (H) | Control Group | 0.30 | 33.33 | 66.67 |
| ADHD Group | 14.74 | 64.29 | 35.71 | |
| Simulation Group | 8.12 | 0.00 | 100.00 | |
| Non-Credible ADHD Group | 5.00 | 100.00 | 0.00 | |
| Total | 2.72 | 29.73 | 70.27 | |
Column denoted ‘%’ shows the percentage of participants within the respective group, whose T-Scores fell into the suspect range (i.e., T ≥ 80)
Agreement between ADHD Credibility Index and Existing Validity Indicators
| Index | Group | Classification | % | ADHD Credibility Index | |
|---|---|---|---|---|---|
| % Not Suspect | % Suspect | ||||
| Inconsistency Index | Control Group | Not Inconsistent | 94.89 | 98.86 | 1.14 |
| Inconsistent | 5.11 | 98.08 | 1.92 | ||
| ADHD Group | Not Inconsistent | 76.60 | 93.06 | 6.94 | |
| Inconsistent | 23.40 | 100.00 | 0.00 | ||
| Simulation Group | Not Inconsistent | 82.48 | 69.43 | 30.57 | |
| Inconsistent | 17.52 | 70.73 | 29.27 | ||
| Non-Credible ADHD Group | Not Inconsistent | 90.00 | 100.00 | 0.00 | |
| Inconsistent | 10.00 | 100.00 | 0.00 | ||
| Total | Not Inconsistent | 91.43 | 94.00 | 6.00 | |
| Inconsistent | 8.57 | 88.89 | 11.11 | ||
| CII | Control Group | Not Suspect | 98.23 | 99.80 | 0.20 |
| Suspect | 1.77 | 44.44 | 55.56 | ||
| ADHD Group | Not Suspect | 69.47 | 100.00 | 0.00 | |
| Suspect | 30.53 | 82.76 | 17.24 | ||
| Simulation Group | Not Suspect | 55.13 | 94.57 | 5.43 | |
| Suspect | 44.87 | 39.05 | 60.95 | ||
| Non-Credible ADHD Group | Not Suspect | 70.00 | 100.00 | 0.00 | |
| Suspect | 30.00 | 100.00 | 0.00 | ||
| Total | Not Suspect | 88.44 | 99.26 | 0.74 | |
| Suspect | 11.56 | 50.00 | 50.00 | ||
Agreement between ADHD Credibility Index (ACI) and CAARS Infrequency Index (CII)
| ACI suspect? | CII suspect? | ||
|---|---|---|---|
| No | Yes | ||
| No | 1200 | 79 | 1279 |
| Yes | 9 | 79 | 88 |
| 1209 | 158 | ||