Prevalence of COVID-19-related symptoms by age group.

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 has caused over 95 million confirmed cases of COVID-19 and over 2 million deaths worldwide. According to current literature data, older adults have higher risk of severe disease and mortality due to COVID-19. It is also known that older adults often do not present typical symptoms of diseases. The aim of the study was to assess if the prevalence of typical COVID-19-related symptoms varies by age group.
METHODS: Medical charts of a random sample of COVID-19 patients dying in-hospital were retrieved through an integrated national surveillance system and reviewed by a group of researchers at the Italian National Institute of Health. Detailed information on COVID-19-related symptoms were extracted and analyzed.
RESULTS: 3241 confirmed cases of COVID-19-related deaths were identified from 4391 reviewed medical charts. The mean number of COVID-19-related symptoms progressively declined with age, from 2.1 in patients aged < 60 years to 1.7 in those aged 90 years or older (p < 0.001). Moreover, fever, cough, and diarrhea significantly declined with increasing age.
CONCLUSIONS: Older adults have atypical presentation of symptoms and may be paucisymptomatic. This may lead to a diagnostic and therapeutic delay which aggravates the prognosis of COVID-19. Special attention should be posed when assessing individuals aged 65 years and older with suspected COVID-19.

Current scientific evidence indicates that older adults have higher risk of severe disease and mortality due to COVID-19, particularly those with comorbidities [1, 2]. The main symptoms of COVID-19, as identified by the Centers of Disease and Control and Prevention, include fever, cough, shortness of breath or difficulty breathing, fatigue, muscle or body aches, headache, loss of taste or smell, sore throat, congestion or runny nose, nausea or vomiting, and diarrhea [3]. However, it is well documented that clinical manifestations of many conditions vary with age and that older adults often do not present typical symptoms of diseases [4, 5]. This can delay diagnosis and worsen prognosis in this population. The aim of the study was to assess if the prevalence of typical COVID-19-related symptoms varies by age group. This analysis was performed in patients dying in-hospital with COVID-19 to define a homogeneous sample and limit possible variability in symptoms presentation due to disease severity.

At the outset of the COVID-19 outbreak, the Italian National Institute of Health (Istituto Superiore di Sanità-ISS) launched an integrated national surveillance system to collect information on individuals with COVID-19 from all 19 Italian Regions and the two autonomous provinces of Trento and Bolzano [1]. Medical charts of a random sample of 4391 patients dying in-hospital were reviewed by a group of researchers at ISS to obtain more detailed information. To compile the medical charts, all patients were asked about their symptoms with the same standardized procedure through anamnesis. In the presence of critically ill patients, the patients’ conditions were reported by relatives, caregivers or health care staff of nursing homes. Data on the following COVID-19-related symptoms prompting hospital admission were collected by the medical staff: fever, dyspnea, cough, diarrhea, and hemoptysis. The recording of the anamnesis was integrated with medical examinations, such as chest imaging through X-ray or computed tomography scan, and laboratory assessments through Reverse Transcription Polymerase Chain Reaction (RT-PCR) testing for COVID-19 confirmation. COVID-19-related deaths were defined as those occurring in patients who tested positive for SARS-CoV-2 through RT-PCR test, which is considered the gold standard in SARS-CoV-2 detection. Patients for whom COVID-19 or COVID-19-related conditions (i.e., pneumonia) were not listed in death certificates (n = 543; 12.4%), those with an admission diagnosis different from COVID-19 (n = 538; 12.3%) and those with incomplete data on symptoms upon admission due to severe condition limiting their ability to give a full medical history (i.e., patients with mental disorders or intubated) were excluded from the analysis (n = 69; 1.6%). Considering that symptoms were collected from patients with serious COVID-19 disease, early symptoms typical of old age, such as those involving the sensorium, may have been missed.

Differences between age groups were evaluated with chi-square test or Fisher’s exact test when appropriate. All analyses were performed using SPSS v. 26.0 (IBM, NY, USA).

Overall, among 3241 cases of COVID-19-related deaths, 74.2% had two or more symptoms (Fig. 1). Mean number of symptoms progressively declined with age from 2.1 in patients aged < 60 years, 2.1 in 60–69, and 2.1 in 70–79, to 1.9 in those aged 80–89 (n = 1301) and to 1.7 in those aged 90 years or older (n = 40) (p < 0.001). The difference in mean number of symptoms was also statistically significant between patients aged < 80 years and those aged 80 years or older (2.1 vs 1.9; p < 0.001). Rate of patients with two or more symptoms progressively declined with age from 80.7% in those aged < 60 years to 63.8% in those aged 90 years or older. Presence of fever, cough, diarrhea and hemoptysis progressively and significantly declined with increasing age.

Fig. 1

Prevalence of typical COVID-19-related symptoms by age group

In conclusion, the older adult population have atypical presentation of symptoms and may be paucisymptomatic even in the case of life-threatening health conditions. Age and disease severity may also affect the patient’s reporting ability. This may lead to a diagnostic and therapeutic delay which aggravates the prognosis of COVID-19. Particular attention should be posed when evaluating individuals aged 65 years and older with suspected COVID-19.