Literature DB >> 3364734

Measurement of total plasma cysteamine using high-performance liquid chromatography with electrochemical detection.

L A Smolin1, J A Schneider.   

Abstract

Cysteamine is currently used to treat children with the inherited disorder nephropathic cystinosis. A method for the quantitative determination of this aminothiol in human plasma is presented. Whole plasma was reduced with sodium borohydride to convert disulfides to thiols. Cysteamine was then separated by high-performance liquid chromatography and detected electrochemically. The recovery of standard cysteamine added to plasma was 96.6 +/- 1.9%. In a patient with cystinosis, an oral dose of cysteamine was absorbed rapidly, with plasma cysteamine reaching a maximum of 56 microM 1 h after the dose. By 1.8 h the plasma cysteamine concentration had decreased to one-half the maximum value.

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Year:  1988        PMID： 3364734     DOI： 10.1016/0003-2697(88)90332-6

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  10 in total

1.  Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.

Authors:  S R Lentz; C G Sobey; D J Piegors; M Y Bhopatkar; F M Faraci; M R Malinow; D D Heistad
Journal:  J Clin Invest       Date:  1996-07-01       Impact factor: 14.808

2.  Effects of oral phosphocysteamine and rectal cysteamine in cystinosis.

Authors:  W G van't Hoff; T Baker; R N Dalton; L C Duke; S P Smith; C Chantler; G B Haycock
Journal:  Arch Dis Child       Date:  1991-12       Impact factor: 3.791

3.  A study of the relative bioavailability of cysteamine hydrochloride, cysteamine bitartrate and phosphocysteamine in healthy adult male volunteers.

Authors:  L Tennezé; V Daurat; A Tibi; P Chaumet-Riffaud; C Funck-Brentano
Journal:  Br J Clin Pharmacol       Date:  1999-01       Impact factor: 4.335

4.  Homocysteine, folate, vitamin B12, and cardiovascular risk in Indians, Malays, and Chinese in Singapore.

Authors:  K Hughes; C N Ong
Journal:  J Epidemiol Community Health       Date:  2000-01       Impact factor: 3.710

5.  Simultaneous determination of total plasma glutathione, homocysteine, cysteinylglycine, and methionine by high-performance liquid chromatography with electrochemical detection.

Authors:  P Houze; S Gamra; I Madelaine; B Bousquet; B Gourmel
Journal:  J Clin Lab Anal       Date:  2001       Impact factor: 2.352

6.  Pharmacokinetics of enteric-coated cysteamine bitartrate in healthy adults: a pilot study.

Authors:  Jon A Gangoiti; Meredith Fidler; Betty L Cabrera; Jerry A Schneider; Bruce A Barshop; Ranjan Dohil
Journal:  Br J Clin Pharmacol       Date:  2010-09       Impact factor: 4.335

7.  Assessment of pre- and post-methionine load homocysteine for prediction of recurrent stroke and coronary artery disease in the Vitamin Intervention for Stroke Prevention Trial.

Authors:  Luther C Pettigrew; Heejung Bang; Lloyd E Chambless; Virginia J Howard; James F Toole
Journal:  Atherosclerosis       Date:  2007-12-31       Impact factor: 5.162

8.  Increased monocyte-dependent suppression of polyclonal activation of B lymphocytes from cystinotic children.

Authors:  G Pintos-Morell; G Jean; M Dechaux; P Niaudet
Journal:  Pediatr Nephrol       Date:  1991-09       Impact factor: 3.714

9.  Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial.

Authors:  A Viswanathan; S Raj; S M Greenberg; M Stampfer; S Campbell; B T Hyman; M C Irizarry
Journal:  Neurology       Date:  2009-01-20       Impact factor: 9.910

10.  Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis.

Authors:  Yasuhiko Kubota; Alvaro Alonso; Susan R Heckbert; Faye L Norby; Aaron R Folsom
Journal:  Heart Lung Circ       Date:  2018-03-21       Impact factor: 2.975
  10 in total

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