Jannis Bodden1,2, Ahmet H Ok1, Gabby B Joseph1, Michael C Nevitt3, Charles E McCulloch3, Nancy E Lane4, Thomas M Link1. 1. Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA. 2. Department of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. 3. Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA. 4. Center for Musculoskeletal Health and Department of Medicine, University of California, Davis, California, USA.
Abstract
BACKGROUND: Adipose tissue has recently gained interest as an independent imaging biomarker for osteoarthritis. PURPOSE: To explore 1) cross-sectional associations between local subcutaneous fat (SCF) thickness at the knee and the extent of degenerative changes in overweight and obese individuals and 2) associations between local fat distribution and progression of osteoarthritis over 4 years. STUDY TYPE: Retrospective cohort study. POPULATION: 338 obese and overweight participants from the Osteoarthritis Initiative cohort without radiographic evidence of osteoarthritis. FIELD STRENGTH: 3T: 3D-FLASH-WE; 3D-DESS-WE; T1w-SE; MSME. ASSESSMENT: Baseline SCF thickness was measured in standardized locations medial, lateral and anterior to the knee and the average joint-adjacent SCF (ajSCF) was calculated. Right thigh SCF cross-sectional area was assessed. Quantitative cartilage T2 relaxation times and semi-quantitative whole organ MRI scores (WORMS) were obtained at baseline and 4-year follow-up. WORMSsum was calculated as sum of cartilage, bone marrow edema, subchondral cyst, and meniscal scores. STATISTICAL TESTS: Associations of SCF measures with baseline, and 4-year change in T2 and WORMS were analyzed using regression models. SCF measurements were standardized using the equation Value Participant - Mean Cohort Standard deviation . Analyses were adjusted for age, sex, physical activity, and BMI. RESULTS: Cross-sectionally, significant associations between lateral SCF, lateral compartment WORMS and T2 were found ( Δ WORMS sum 1 SD change in lateral SCF , [95% CI]: 0.53, [0.12-0.95], P < 0.05; ΔT2 : 0.50, [0.02-0.98], P < 0.05). Moreover, greater lateral SCF was associated with faster progression of lateral WORMSsum gradings (OR = 1.50, [1.05-2.15], P < 0.05). No significant positive associations were found for thigh SCF and WORMSsum (P = 0.44) or T2 measurements (medial: P = 0.15, lateral: 0.39, patellar: P = 0.75). DATA CONCLUSION: Joint-adjacent SCF thickness was associated with imaging parameters of knee osteoarthritis, both cross-sectionally and longitudinally, while thigh SCF was not, suggesting a spatial association of SCF and knee osteoarthritis. Based on these findings, joint-adjacent SCF may play a role in the development and progression of knee osteoarthritis. LEVEL OF EVIDENCE: 4 TECHNICAL EFFICACY: Stage 5.
BACKGROUND: Adipose tissue has recently gained interest as an independent imaging biomarker for osteoarthritis. PURPOSE: To explore 1) cross-sectional associations between local subcutaneous fat (SCF) thickness at the knee and the extent of degenerative changes in overweight and obese individuals and 2) associations between local fat distribution and progression of osteoarthritis over 4 years. STUDY TYPE: Retrospective cohort study. POPULATION: 338 obese and overweight participants from the Osteoarthritis Initiative cohort without radiographic evidence of osteoarthritis. FIELD STRENGTH: 3T: 3D-FLASH-WE; 3D-DESS-WE; T1w-SE; MSME. ASSESSMENT: Baseline SCF thickness was measured in standardized locations medial, lateral and anterior to the knee and the average joint-adjacent SCF (ajSCF) was calculated. Right thigh SCF cross-sectional area was assessed. Quantitative cartilage T2 relaxation times and semi-quantitative whole organ MRI scores (WORMS) were obtained at baseline and 4-year follow-up. WORMSsum was calculated as sum of cartilage, bone marrow edema, subchondral cyst, and meniscal scores. STATISTICAL TESTS: Associations of SCF measures with baseline, and 4-year change in T2 and WORMS were analyzed using regression models. SCF measurements were standardized using the equation Value Participant - Mean Cohort Standard deviation . Analyses were adjusted for age, sex, physical activity, and BMI. RESULTS: Cross-sectionally, significant associations between lateral SCF, lateral compartment WORMS and T2 were found ( Δ WORMS sum 1 SD change in lateral SCF , [95% CI]: 0.53, [0.12-0.95], P < 0.05; ΔT2 : 0.50, [0.02-0.98], P < 0.05). Moreover, greater lateral SCF was associated with faster progression of lateral WORMSsum gradings (OR = 1.50, [1.05-2.15], P < 0.05). No significant positive associations were found for thigh SCF and WORMSsum (P = 0.44) or T2 measurements (medial: P = 0.15, lateral: 0.39, patellar: P = 0.75). DATA CONCLUSION: Joint-adjacent SCF thickness was associated with imaging parameters of knee osteoarthritis, both cross-sectionally and longitudinally, while thigh SCF was not, suggesting a spatial association of SCF and knee osteoarthritis. Based on these findings, joint-adjacent SCF may play a role in the development and progression of knee osteoarthritis. LEVEL OF EVIDENCE: 4 TECHNICAL EFFICACY: Stage 5.
Authors: C Stehling; T Baum; C Mueller-Hoecker; H Liebl; J Carballido-Gamio; G B Joseph; S Majumdar; T M Link Journal: Osteoarthritis Cartilage Date: 2011-04-12 Impact factor: 6.576
Authors: G B Joseph; T Baum; H Alizai; J Carballido-Gamio; L Nardo; W Virayavanich; J A Lynch; M C Nevitt; C E McCulloch; S Majumdar; T M Link Journal: Osteoarthritis Cartilage Date: 2012-04-11 Impact factor: 6.576
Authors: Shirley Aparecida Fabris de Souza; Joel Faintuch; Antonio Carlos Valezi; Antonio Fernando Sant' Anna; Joaquim José Gama-Rodrigues; Inês Cristina de Batista Fonseca; Roger Burgo Souza; Roger Christian Senhorini Journal: Obes Surg Date: 2005-10 Impact factor: 4.129
Authors: F P B Kroon; A I Veenbrink; R de Mutsert; A W Visser; K W van Dijk; S le Cessie; F R Rosendaal; M Kloppenburg Journal: Osteoarthritis Cartilage Date: 2019-08-23 Impact factor: 6.576