Yichen Guo1, Dawei Wu1, Zhifu Sun1, Linyin Yao1, Jia Liu1, Yongxiang Wei2,3. 1. Department of Otolaryngology, Smell and Taste Center, Beijing Anzhen Hospital, Capital Medical University, Anzhen Road 2, Chaoyang District, Beijing, 100029, China. 2. Department of Otolaryngology, Smell and Taste Center, Beijing Anzhen Hospital, Capital Medical University, Anzhen Road 2, Chaoyang District, Beijing, 100029, China. weiyx_azent@sina.com. 3. Department of Otorhinolaryngology Head and Neck Surgery, Capital Institute of Pediatrics, Beijing, China. weiyx_azent@sina.com.
Abstract
PURPOSE: Prognostic assessment of patients with post-infectious olfactory dysfunction (PIOD) poses a challenge for clinicians. While there have been some studies on the prognostic factors of PIOD focusing on demographic factors, the aim of this study was to investigate whether event-related potentials (ERPs) could be used as a new predictor of olfactory recovery in PIOD. METHODS: This was a retrospective study involving patients who underwent olfactory examinations using Sniffin' Sticks test before treatment and after 1 year of follow-up. The responder group was defined by an increase of threshold-discrimination-identification (TDI) score of ≥ 6 points. All patients underwent ERP examination and the amplitude and latency of each wave of ERPs were recorded before treatment. RESULTS: A total of 61 patients (age 47.50 ± 11.04 years, 27 males) were analyzed. The presence of olfactory ERPs (oERPs) was greater in the responder group than in the non-responder group (P = 0.007), while that of trigeminal ERPs (tERPs) did not differ between the two groups (P = 0.346). Logistic-regression analyses showed that factors associated with improvement of subjective olfactory function were duration (OR, 1.604; 95% CI, 1.062-2.423; P = 0.025), initial threshold (odds ratio [OR], 0.043; 95% confidence interval [CI], 0.004-0.439; P = 0.008), and latency of N1 in oERPs (OR, 1.007; 95% CI, 1.001-1.013; P = 0.021). CONCLUSION: Our study shows that duration of OD, initial threshold, and latency of N1 in oERPs were associated with olfactory improvement in PIOD patients, which may provide guidance for clinicians.
PURPOSE: Prognostic assessment of patients with post-infectious olfactory dysfunction (PIOD) poses a challenge for clinicians. While there have been some studies on the prognostic factors of PIOD focusing on demographic factors, the aim of this study was to investigate whether event-related potentials (ERPs) could be used as a new predictor of olfactory recovery in PIOD. METHODS: This was a retrospective study involving patients who underwent olfactory examinations using Sniffin' Sticks test before treatment and after 1 year of follow-up. The responder group was defined by an increase of threshold-discrimination-identification (TDI) score of ≥ 6 points. All patients underwent ERP examination and the amplitude and latency of each wave of ERPs were recorded before treatment. RESULTS: A total of 61 patients (age 47.50 ± 11.04 years, 27 males) were analyzed. The presence of olfactory ERPs (oERPs) was greater in the responder group than in the non-responder group (P = 0.007), while that of trigeminal ERPs (tERPs) did not differ between the two groups (P = 0.346). Logistic-regression analyses showed that factors associated with improvement of subjective olfactory function were duration (OR, 1.604; 95% CI, 1.062-2.423; P = 0.025), initial threshold (odds ratio [OR], 0.043; 95% confidence interval [CI], 0.004-0.439; P = 0.008), and latency of N1 in oERPs (OR, 1.007; 95% CI, 1.001-1.013; P = 0.021). CONCLUSION: Our study shows that duration of OD, initial threshold, and latency of N1 in oERPs were associated with olfactory improvement in PIOD patients, which may provide guidance for clinicians.
Authors: M Damm; A Temmel; A Welge-Lüssen; H E Eckel; M-P Kreft; J P Klussmann; H Gudziol; K-B Hüttenbrink; T Hummel Journal: HNO Date: 2004-02 Impact factor: 1.284
Authors: Janina Seubert; Erika J Laukka; Debora Rizzuto; Thomas Hummel; Laura Fratiglioni; Lars Bäckman; Maria Larsson Journal: J Gerontol A Biol Sci Med Sci Date: 2017-08-01 Impact factor: 6.053
Authors: T Hummel; K L Whitcroft; P Andrews; A Altundag; C Cinghi; R M Costanzo; M Damm; J Frasnelli; H Gudziol; N Gupta; A Haehner; E Holbrook; S C Hong; D Hornung; K B Hüttenbrink; R Kamel; M Kobayashi; I Konstantinidis; B N Landis; D A Leopold; A Macchi; T Miwa; R Moesges; J Mullol; C A Mueller; G Ottaviano; G C Passali; C Philpott; J M Pinto; V J Ramakrishnan; P Rombaux; Y Roth; R A Schlosser; B Shu; G Soler; P Stjärne; B A Stuck; J Vodicka; A Welge-Luessen Journal: Rhinology Date: 2016-01-31 Impact factor: 3.681