Vega Widya Karisma1, Wei Wu1, Mingxing Lei1, Huawen Liu2, Muhammad Farrukh Nisar3, Matthew D Lloyd4, Charareh Pourzand5,6, Julia Li Zhong1. 1. Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China. 2. Three Gorges Central Hospital, Chongqing, China. 3. Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur, Pakistan. 4. Drug and Target Discovery, Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom. 5. Medicines Design, Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom. 6. Medicines Development, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom.
Abstract
Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a "switch on- switch off" procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.
Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (n class="Chemical">UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a "switch on- switch off" procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.
Keywords:
UVA-triggered drug release; caged iron chelators; drug delivery systems (DDS); skin photo-protection; smart sunscreens; up-conversion nanoparticles