Literature DB >> 33641869

Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology.

Daniel Royston1, Adam J Mead2, Bethan Psaila3.   

Abstract

Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Digital pathology; Myeloproliferative neoplasm; Single-cell genomics

Mesh：

Year:  2021        PMID： 33641869      PMCID： PMC7935666          DOI： 10.1016/j.hoc.2021.01.002

Source DB:  PubMed          Journal:  Hematol Oncol Clin North Am        ISSN： 0889-8588            Impact factor:   3.722


  89 in total

1.  WHO-histological criteria for myeloproliferative neoplasms: reproducibility, diagnostic accuracy and correlation with gene mutations and clinical outcomes.

Authors:  Alberto Alvarez-Larrán; Agueda Ancochea; Mar García; Fina Climent; Francesc García-Pallarols; Anna Angona; Alicia Senín; Carlos Barranco; Luz Martínez-Avilés; Sergio Serrano; Beatriz Bellosillo; Carlos Besses
Journal:  Br J Haematol       Date:  2014-06-24       Impact factor: 6.998

Review 2.  Deep learning.

Authors:  Yann LeCun; Yoshua Bengio; Geoffrey Hinton
Journal:  Nature       Date:  2015-05-28       Impact factor: 49.962

3.  CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes.

Authors:  Mirjana Efremova; Miquel Vento-Tormo; Sarah A Teichmann; Roser Vento-Tormo
Journal:  Nat Protoc       Date:  2020-02-26       Impact factor: 13.491

4.  Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.

Authors:  E Joanna Baxter; Linda M Scott; Peter J Campbell; Clare East; Nasios Fourouclas; Soheila Swanton; George S Vassiliou; Anthony J Bench; Elaine M Boyd; Natasha Curtin; Mike A Scott; Wendy N Erber; Anthony R Green
Journal:  Lancet       Date:  2005 Mar 19-25       Impact factor: 79.321

5.  Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis.

Authors:  Paola Guglielmelli; Annalisa Pacilli; Giada Rotunno; Elisa Rumi; Vittorio Rosti; Federica Delaini; Margherita Maffioli; Tiziana Fanelli; Alessandro Pancrazzi; Daniela Pietra; Silvia Salmoiraghi; Carmela Mannarelli; Annalisa Franci; Chiara Paoli; Alessandro Rambaldi; Francesco Passamonti; Giovanni Barosi; Tiziano Barbui; Mario Cazzola; Alessandro M Vannucchi
Journal:  Blood       Date:  2017-03-28       Impact factor: 25.476

6.  PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells.

Authors:  F Alexander Wolf; Fiona K Hamey; Mireya Plass; Jordi Solana; Joakim S Dahlin; Berthold Göttgens; Nikolaus Rajewsky; Lukas Simon; Fabian J Theis
Journal:  Genome Biol       Date:  2019-03-19       Impact factor: 13.583

7.  Somatic mutations and cell identity linked by Genotyping of Transcriptomes.

Authors:  Anna S Nam; Kyu-Tae Kim; Ronan Chaligne; Franco Izzo; Chelston Ang; Justin Taylor; Robert M Myers; Ghaith Abu-Zeinah; Ryan Brand; Nathaniel D Omans; Alicia Alonso; Caroline Sheridan; Marisa Mariani; Xiaoguang Dai; Eoghan Harrington; Alessandro Pastore; Juan R Cubillos-Ruiz; Wayne Tam; Ronald Hoffman; Raul Rabadan; Joseph M Scandura; Omar Abdel-Wahab; Peter Smibert; Dan A Landau
Journal:  Nature       Date:  2019-07-03       Impact factor: 49.962

8.  The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production.

Authors:  Daniel Prins; Hyun Jung Park; Sam Watcham; Juan Li; Michele Vacca; Hugo P Bastos; Alexander Gerbaulet; Antonio Vidal-Puig; Berthold Göttgens; Anthony R Green
Journal:  Sci Adv       Date:  2020-11-25       Impact factor: 14.136

9.  Mutational heterogeneity in cancer and the search for new cancer-associated genes.

Authors:  Michael S Lawrence; Petar Stojanov; Paz Polak; Gregory V Kryukov; Kristian Cibulskis; Andrey Sivachenko; Scott L Carter; Chip Stewart; Craig H Mermel; Steven A Roberts; Adam Kiezun; Peter S Hammerman; Aaron McKenna; Yotam Drier; Lihua Zou; Alex H Ramos; Trevor J Pugh; Nicolas Stransky; Elena Helman; Jaegil Kim; Carrie Sougnez; Lauren Ambrogio; Elizabeth Nickerson; Erica Shefler; Maria L Cortés; Daniel Auclair; Gordon Saksena; Douglas Voet; Michael Noble; Daniel DiCara; Pei Lin; Lee Lichtenstein; David I Heiman; Timothy Fennell; Marcin Imielinski; Bryan Hernandez; Eran Hodis; Sylvan Baca; Austin M Dulak; Jens Lohr; Dan-Avi Landau; Catherine J Wu; Jorge Melendez-Zajgla; Alfredo Hidalgo-Miranda; Amnon Koren; Steven A McCarroll; Jaume Mora; Brian Crompton; Robert Onofrio; Melissa Parkin; Wendy Winckler; Kristin Ardlie; Stacey B Gabriel; Charles W M Roberts; Jaclyn A Biegel; Kimberly Stegmaier; Adam J Bass; Levi A Garraway; Matthew Meyerson; Todd R Golub; Dmitry A Gordenin; Shamil Sunyaev; Eric S Lander; Gad Getz
Journal:  Nature       Date:  2013-06-16       Impact factor: 49.962

10.  Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells.

Authors:  Erik L Bao; Satish K Nandakumar; Xiaotian Liao; Alexander G Bick; Juha Karjalainen; Marcin Tabaka; Olga I Gan; Aki S Havulinna; Tuomo T J Kiiskinen; Caleb A Lareau; Aitzkoa L de Lapuente Portilla; Bo Li; Connor Emdin; Veryan Codd; Christopher P Nelson; Christopher J Walker; Claire Churchhouse; Albert de la Chapelle; Daryl E Klein; Björn Nilsson; Peter W F Wilson; Kelly Cho; Saiju Pyarajan; J Michael Gaziano; Nilesh J Samani; Aviv Regev; Aarno Palotie; Benjamin M Neale; John E Dick; Pradeep Natarajan; Christopher J O'Donnell; Mark J Daly; Michael Milyavsky; Sekar Kathiresan; Vijay G Sankaran
Journal:  Nature       Date:  2020-10-14       Impact factor: 69.504
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