Literature DB >> 33641866

Epigenetic Dysregulation of Myeloproliferative Neoplasms.

Andrew Dunbar1, Young Park2, Ross Levine3.   

Abstract

This article reviews the genetic data on epigenetic modifying mutations in myeloproliferative neoplasms and their clinical implications, preclinical studies exploring our current understanding of how mutations in epigenetic modifying proteins cooperate with myeloproliferative neoplasms drivers to promote disease progression, and recent advances in novel therapeutics supporting the role of targeting epigenetic pathways to treat fibrotic progression.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Epigenetic pathways; Epigenetics of MPN; Fibrotic progression; Myelofibrosis; Myeloproliferative neoplasms; Preclinical studies

Mesh：

Year:  2021        PMID： 33641866      PMCID： PMC7927771          DOI： 10.1016/j.hoc.2021.01.001

Source DB:  PubMed          Journal:  Hematol Oncol Clin North Am        ISSN： 0889-8588            Impact factor:   3.722


  71 in total

Review 1.  Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

Authors:  Katrina J Falkenberg; Ricky W Johnstone
Journal:  Nat Rev Drug Discov       Date:  2014-08-18       Impact factor: 84.694

2.  A phase II study of 5-azacitidine for patients with primary and post-essential thrombocythemia/polycythemia vera myelofibrosis.

Authors:  A Quintás-Cardama; W Tong; H Kantarjian; D Thomas; F Ravandi; S Kornblau; T Manshouri; J E Cortes; G Garcia-Manero; S Verstovsek
Journal:  Leukemia       Date:  2008-04-03       Impact factor: 11.528

3.  Lysine-specific demethylase 1 (LSD1) in hematopoietic and lymphoid neoplasms.

Authors:  Dennis Niebel; Jutta Kirfel; Viktor Janzen; Tobias Höller; Michael Majores; Ines Gütgemann
Journal:  Blood       Date:  2014-07-03       Impact factor: 22.113

4.  Effect of mutation order on myeloproliferative neoplasms.

Authors:  Christina A Ortmann; David G Kent; Jyoti Nangalia; Yvonne Silber; David C Wedge; Jacob Grinfeld; E Joanna Baxter; Charles E Massie; Elli Papaemmanuil; Suraj Menon; Anna L Godfrey; Danai Dimitropoulou; Paola Guglielmelli; Beatriz Bellosillo; Carles Besses; Konstanze Döhner; Claire N Harrison; George S Vassiliou; Alessandro Vannucchi; Peter J Campbell; Anthony R Green
Journal:  N Engl J Med       Date:  2015-02-12       Impact factor: 91.245

5.  IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

Authors:  A Tefferi; T L Lasho; O Abdel-Wahab; P Guglielmelli; J Patel; D Caramazza; L Pieri; C M Finke; O Kilpivaara; M Wadleigh; M Mai; R F McClure; D G Gilliland; R L Levine; A Pardanani; A M Vannucchi
Journal:  Leukemia       Date:  2010-05-27       Impact factor: 12.883

6.  PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN.

Authors:  Friederike Pastore; Neha Bhagwat; Alessandro Pastore; Aliaksandra Radzisheuskaya; Abdul Karzai; Aishwarya Krishnan; Bing Li; Robert L Bowman; Wenbin Xiao; Aaron D Viny; Anouar Zouak; Young C Park; Keith B Cordner; Stephanie Braunstein; Jesper L Maag; Alexander Grego; Jaanvi Mehta; Min Wang; Hong Lin; Benjamin H Durham; Richard P Koche; Raajit K Rampal; Kristian Helin; Peggy Scherle; Kris Vaddi; Ross L Levine
Journal:  Cancer Discov       Date:  2020-07-15       Impact factor: 38.272

7.  The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model.

Authors:  Yueh-Chwen Hsu; Yu-Chiao Chiu; Chien-Chin Lin; Yuan-Yeh Kuo; Hsin-An Hou; Yi-Shiuan Tzeng; Chein-Jun Kao; Po-Han Chuang; Mei-Hsuan Tseng; Tzu-Hung Hsiao; Wen-Chien Chou; Hwei-Fang Tien
Journal:  J Hematol Oncol       Date:  2017-07-11       Impact factor: 17.388

8.  LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone.

Authors:  Jonas S Jutzi; Maria Kleppe; Jennifer Dias; Hans Felix Staehle; Kaitlyn Shank; Julie Teruya-Feldstein; Sudheer Madan Mohan Gambheer; Christine Dierks; Hugh Y Rienhoff; Ross L Levine; Heike L Pahl
Journal:  Hemasphere       Date:  2018-06-08

9.  Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal.

Authors:  Mairi S Shepherd; Juan Li; Nicola K Wilson; Caroline A Oedekoven; Jiangbing Li; Miriam Belmonte; Juergen Fink; Janine C M Prick; Dean C Pask; Tina L Hamilton; Dirk Loeffler; Anjana Rao; Timm Schröder; Berthold Göttgens; Anthony R Green; David G Kent
Journal:  Blood       Date:  2018-07-10       Impact factor: 22.113
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