Seyit Ali Gümüştaş1, Zekeriya Ersin Çelen2, Tolga Onay1, Mehmet Süleyman Abul1, Hüseyin Bilgehan Çevik3. 1. Department of Orthopaedics and Traumatology, Kartal Dr. Lütfi Kırdar City Hospital, University of Health Sciences, Istanbul, Turkey. 2. Department of Orthopaedics and Traumatology, Yalova Public Hospital, Yalova, Turkey. drersincelen@gmail.com. 3. Department of Orthopaedics and Traumatology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Abstract
PURPOSE: This study aimed to investigate the efficiency and safety of tranexamic acid use in open reduction and internal fixation of pelvis and acetabulum fractures. MATERIALS AND METHODS: 73 consecutive patients were included. 1000 mg TXA was administered intravenously to all patients before surgery. The patients were evaluated on the basis of preoperative, postoperative first and third day hemoglobin-hematocrit values, amount of drainage collected, total blood loss, transfusion rates and complications. RESULTS: Mean operative time was 120.1 min. Average decrease in hematocrit levels between preoperative and postoperative first day was 2.1 g/dL. Average collected blood from the drain was 177 mL. Mean total blood loss was 1137 mL. Transfusion rate of the patients was 21%. Mean transfused units was 0.9 units. Three patients died within 3 weeks after the operation due to myocardial infarction, acute kidney failure and pneumonia. There were no cases of symptomatic venous or pulmonary thromboembolism during the 90 days of follow-up. CONCLUSION: Use of TXA in pelvic and acetabular fractures was found to be effective in reducing total blood loss, hemoglobin drop and transfusion rates without increasing venous and pulmonary thromboembolism in our series.
PURPOSE: This study aimed to investigate the efficiency and safety of tranexamic acid use in open reduction and internal fixation of pelvis and acetabulum fractures. MATERIALS AND METHODS: 73 consecutive patients were included. 1000 mg TXA was administered intravenously to all patients before surgery. The patients were evaluated on the basis of preoperative, postoperative first and third day hemoglobin-hematocrit values, amount of drainage collected, total blood loss, transfusion rates and complications. RESULTS: Mean operative time was 120.1 min. Average decrease in hematocrit levels between preoperative and postoperative first day was 2.1 g/dL. Average collected blood from the drain was 177 mL. Mean total blood loss was 1137 mL. Transfusion rate of the patients was 21%. Mean transfused units was 0.9 units. Three patients died within 3 weeks after the operation due to myocardial infarction, acute kidney failure and pneumonia. There were no cases of symptomatic venous or pulmonary thromboembolism during the 90 days of follow-up. CONCLUSION: Use of TXA in pelvic and acetabular fractures was found to be effective in reducing total blood loss, hemoglobin drop and transfusion rates without increasing venous and pulmonary thromboembolism in our series.
Authors: J L Carson; D G Altman; A Duff; H Noveck; M P Weinstein; F A Sonnenberg; J I Hudson; G Provenzano Journal: Transfusion Date: 1999-07 Impact factor: 3.157
Authors: P Innerhofer; G Luz; L Spötl; P Hobisch-Hagen; W Schobersberger; M Fischer; W Nussbaumer; A Lochs; E Irschick Journal: Transfusion Date: 1999-10 Impact factor: 3.157
Authors: Joshua S Everhart; John H Sojka; Joel L Mayerson; Andrew H Glassman; Thomas J Scharschmidt Journal: J Bone Joint Surg Am Date: 2018-02-21 Impact factor: 5.284
Authors: Christian Fisahn; Shiveindra Jeyamohan; Daniel C Norvell; Richard S Tubbs; Marc Moisi; Jens R Chapman; Jeni Page; Rod J Oskouian Journal: Clin Spine Surg Date: 2017-08 Impact factor: 1.876
Authors: Grant V Bochicchio; Lena Napolitano; Manjari Joshi; Kelly Bochicchio; Walter Meyer; Thomas M Scalea Journal: World J Surg Date: 2008-10 Impact factor: 3.352
Authors: Shahid Miangul; Timothy Oluwaremi; Joe El Haddad; Maamoun Adra; Nathan Pinnawala; Hayato Nakanishi; Reem H Matar; Christian A Than; Thomas M Stewart Journal: Eur J Orthop Surg Traumatol Date: 2022-09-26