Jinlu Dai1, Alison B Shupp2, Karen M Bussard2, Evan T Keller3,4. 1. Department of Urology, University of Michigan, NCRC B14 RM116, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. 2. Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA. 3. Department of Urology, University of Michigan, NCRC B14 RM116, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. etkeller@umich.edu. 4. Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA. etkeller@umich.edu.
Abstract
PURPOSE OF REVIEW: In this review, we describe the biology of extracellular vesicles (EV) and how they contribute to bone-associated cancers. RECENT FINDINGS: Crosstalk between tumor and bone has been demonstrated to promote tumor and metastatic progression. In addition to direct cell-to-cell contact and soluble factors, such as cytokines, EVs mediate crosstalk between tumor and bone. EVs are composed of a heterogenous group of membrane-delineated vesicles of varying size range, mechanisms of formation, and content. These include apoptotic bodies, microvesicles, large oncosomes, and exosomes. EVs derived from primary tumors have been shown to alter bone remodeling and create formation of a pre-metastatic niche that favors development of bone metastasis. Similarly, EVs from marrow stromal cells have been shown to promote tumor progression. Additionally, EVs can act as therapeutic delivery vehicles due to their low immunogenicity and targeting specificity. EVs play critical roles in intercellular communication. Multiple classes of EVs exist based on size on mechanism of formation. In addition to a role in pathophysiology, EVs can be exploited as therapeutic delivery vehicles.
PURPOSE OF REVIEW: In this review, we describe the biology of extracellular vesicles (EV) and how they contribute to bone-associated cancers. RECENT FINDINGS: Crosstalk between tumor and bone has been demonstrated to promote tumor and metastatic progression. In addition to direct cell-to-cell contact and soluble factors, such as cytokines, EVs mediate crosstalk between tumor and bone. EVs are composed of a heterogenous group of membrane-delineated vesicles of varying size range, mechanisms of formation, and content. These include apoptotic bodies, microvesicles, large oncosomes, and exosomes. EVs derived from primary tumors have been shown to alter bone remodeling and create formation of a pre-metastatic niche that favors development of bone metastasis. Similarly, EVs from marrow stromal cells have been shown to promote tumor progression. Additionally, EVs can act as therapeutic delivery vehicles due to their low immunogenicity and targeting specificity. EVs play critical roles in intercellular communication. Multiple classes of EVs exist based on size on mechanism of formation. In addition to a role in pathophysiology, EVs can be exploited as therapeutic delivery vehicles.
Authors: A Bergsmedh; A Szeles; M Henriksson; A Bratt; M J Folkman; A L Spetz; L Holmgren Journal: Proc Natl Acad Sci U S A Date: 2001-05-15 Impact factor: 11.205
Authors: Haiying Zhang; Daniela Freitas; Han Sang Kim; Kristina Fabijanic; Zhong Li; Haiyan Chen; Milica Tesic Mark; Henrik Molina; Alberto Benito Martin; Linda Bojmar; Justin Fang; Sham Rampersaud; Ayuko Hoshino; Irina Matei; Candia M Kenific; Miho Nakajima; Anders Peter Mutvei; Pasquale Sansone; Weston Buehring; Huajuan Wang; Juan Pablo Jimenez; Leona Cohen-Gould; Navid Paknejad; Matthew Brendel; Katia Manova-Todorova; Ana Magalhães; José Alexandre Ferreira; Hugo Osório; André M Silva; Ashish Massey; Juan R Cubillos-Ruiz; Giuseppe Galletti; Paraskevi Giannakakou; Ana Maria Cuervo; John Blenis; Robert Schwartz; Mary Sue Brady; Héctor Peinado; Jacqueline Bromberg; Hiroshi Matsui; Celso A Reis; David Lyden Journal: Nat Cell Biol Date: 2018-02-19 Impact factor: 28.824