Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Advances in the Microbial Synthesis of 5-Hydroxytryptophan.

Literature DB >> 33634088

Advances in the Microbial Synthesis of 5-Hydroxytryptophan.

Xin-Xin Liu¹, Bin Zhang², Lian-Zhong Ai¹.

Abstract

5-Hydroxytryptophan (5-HTP) plays an important role in the regulation of emotion, behavior, sleep, pain, body temperature, and other physiological functions. It is used in the treatment of depression, insomnia, migraine, and other diseases. Due to a lack of effective biosynthesis methods, 5-HTP is mainly obtained by natural extraction, which has been unable to meet the needs of the market. Through the directed evolution of enzymes and the introduction of substrate supply pathways, 5-HTP biosynthesis and yield increase have been realized. This review provides examples that illustrate the production mode of 5-HTP and the latest progress in microbial synthesis.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: 5-hydroxytryptophan; L-trp; biosynthesis; tetrahydrobiopterin; tryptophan hydroxylase

Year: 2021 PMID： 33634088 PMCID： PMC7901931 DOI： 10.3389/fbioe.2021.624503

Source DB: PubMed Journal: Front Bioeng Biotechnol ISSN： 2296-4185

38 in total

1. Pterin-Dependent Amino Acid Hydroxylases.

Authors: T. Joseph Kappock; John P. Caradonna
Journal: Chem Rev Date: 1996-11-07 Impact factor: 60.622

2. Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy.

Authors: M Nicolodi; F Sicuteri
Journal: Adv Exp Med Biol Date: 1996 Impact factor: 2.622

3. Serotonin precursors in migraine prophylaxis.

Authors: G Bono; M Criscuoli; E Martignoni; S Salmon; G Nappi
Journal: Adv Neurol Date: 1982

4. Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum.

Authors: Kuniki Kino; Ryotaro Hara; Ai Nozawa
Journal: J Biosci Bioeng Date: 2009-09 Impact factor: 2.894

5. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial.

Authors: F Titus; A Dávalos; J Alom; A Codina
Journal: Eur Neurol Date: 1986 Impact factor: 1.710

Review 6. Mechanisms of tryptophan and tyrosine hydroxylase.

Authors: Kenneth M Roberts; Paul F Fitzpatrick
Journal: IUBMB Life Date: 2013-02-26 Impact factor: 3.885

7. A unique central tryptophan hydroxylase isoform.

Authors: Diego J Walther; Michael Bader
Journal: Biochem Pharmacol Date: 2003-11-01 Impact factor: 5.858

8. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland.

Authors: Paresh D Patel; Crystal Pontrello; Sharon Burke
Journal: Biol Psychiatry Date: 2004-02-15 Impact factor: 13.382

9. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo.

Authors: G De Benedittis; R Massei
Journal: J Neurosurg Sci Date: 1985 Jul-Sep Impact factor: 2.279

Advances in the Microbial Synthesis of 5-Hydroxytryptophan.

1. Pterin-Dependent Amino Acid Hydroxylases.

2. Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy.

3. Serotonin precursors in migraine prophylaxis.

4. Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum.

5. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial.

Review 6. Mechanisms of tryptophan and tyrosine hydroxylase.

7. A unique central tryptophan hydroxylase isoform.

8. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland.

9. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo.

10. Enhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration.

Review 1. Melatonin biosynthesis pathways in nature and its production in engineered microorganisms.

2. Pulmonary embolism and 529 human blood metabolites: genetic correlation and two-sample Mendelian randomization study.

3. Metabolic engineering of Escherichia coli for efficient production of L-5-hydroxytryptophan from glucose.

4. Construction of cell factory capable of efficiently converting L-tryptophan into 5-hydroxytryptamine.