PURPOSE: Aim of this study was to investigate the association between postdiagnosis body mass index (BMI) and all-cause mortality in colorectal cancer (CRC) survivors in a prospective study and meta-analysis. METHODS: We conducted a prospective cohort study on 2,143 CRC survivors in Germany. Participants were recruited to the study on average 4 years after diagnosis, and postdiagnosis BMI was assessed at recruitment using a self-administered questionnaire. CRC survivors were followed up for a mean time of 3.5 years. The association between BMI and all-cause mortality was investigated using multivariable Cox proportional hazards models. Additionally, we performed a meta-analysis of studies on postdiagnosis BMI and all-cause mortality (n = 5, including this study) by applying random-effects models. RESULTS: In the prospective analysis, 349 participants died. BMI was not statistically significantly associated with all-cause mortality. Compared to normal weight survivors, the hazard ratios (HRs) [95% confidence interval (CI)] for all-cause mortality in underweight, overweight and obese survivors were 1.65 (0.79-3.45), 0.80 (0.62-1.03) and 0.84 (0.62-1.14), respectively. In the meta-analysis, individuals with underweight were at increased risk for all-cause mortality [HR (95% CI) 1.72 (1.18-2.49)], whereas individuals with overweight had a lower risk [HR (95% CI) 0.79 (0.71-0.88)], compared to normal weight subjects. For obesity, the risk of mortality was also reduced with only borderline significance [HR (95% CI) 0.88 (0.77-1.00)]. CONCLUSIONS: While the present study as well as single previously published studies showed that overweight was associated with a non-significant reduced risk for all-cause mortality, our meta-analysis indicated a decreased mortality risk among overweight CRC survivors.
PURPOSE: Aim of this study was to investigate the association between postdiagnosis body mass index (BMI) and all-cause mortality in colorectal cancer (CRC) survivors in a prospective study and meta-analysis. METHODS: We conducted a prospective cohort study on 2,143 CRC survivors in Germany. Participants were recruited to the study on average 4 years after diagnosis, and postdiagnosis BMI was assessed at recruitment using a self-administered questionnaire. CRC survivors were followed up for a mean time of 3.5 years. The association between BMI and all-cause mortality was investigated using multivariable Cox proportional hazards models. Additionally, we performed a meta-analysis of studies on postdiagnosis BMI and all-cause mortality (n = 5, including this study) by applying random-effects models. RESULTS: In the prospective analysis, 349 participants died. BMI was not statistically significantly associated with all-cause mortality. Compared to normal weight survivors, the hazard ratios (HRs) [95% confidence interval (CI)] for all-cause mortality in underweight, overweight and obese survivors were 1.65 (0.79-3.45), 0.80 (0.62-1.03) and 0.84 (0.62-1.14), respectively. In the meta-analysis, individuals with underweight were at increased risk for all-cause mortality [HR (95% CI) 1.72 (1.18-2.49)], whereas individuals with overweight had a lower risk [HR (95% CI) 0.79 (0.71-0.88)], compared to normal weight subjects. For obesity, the risk of mortality was also reduced with only borderline significance [HR (95% CI) 0.88 (0.77-1.00)]. CONCLUSIONS: While the present study as well as single previously published studies showed that overweight was associated with a non-significant reduced risk for all-cause mortality, our meta-analysis indicated a decreased mortality risk among overweight CRC survivors.
Authors: Jung Hwan Lee; Boram Park; Jungnam Joo; Myeong-Cherl Kook; Young-Il Kim; Jong Yeul Lee; Chan Gyoo Kim; Il Ju Choi; Bang Wool Eom; Hong Man Yoon; Keun Won Ryu; Young-Woo Kim; Soo-Jeong Cho Journal: Gastric Cancer Date: 2018-04-12 Impact factor: 7.370
Authors: Bette J Caan; Jeffrey A Meyerhardt; Candyce H Kroenke; Stacey Alexeeff; Jingjie Xiao; Erin Weltzien; Elizabeth Cespedes Feliciano; Adrienne L Castillo; Charles P Quesenberry; Marilyn L Kwan; Carla M Prado Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-05-15 Impact factor: 4.254
Authors: Adam Rzechonek; Piotr Błasiak; Grzegorz Pniewski; Piotr Cierpikowski; Monika Mościbrodzka; Maciej Ornat; Jędrzej Grzegrzółka; Anna Brzecka Journal: In Vivo Date: 2018 Jan-Feb Impact factor: 2.155
Authors: Elizabeth M Cespedes Feliciano; Candyce H Kroenke; Jeffrey A Meyerhardt; Carla M Prado; Patrick T Bradshaw; Andrew J Dannenberg; Marilyn L Kwan; Jingjie Xiao; Charles Quesenberry; Erin K Weltzien; Adrienne L Castillo; Bette J Caan Journal: J Clin Oncol Date: 2016-10-20 Impact factor: 44.544
Authors: Jeffrey A Meyerhardt; Candyce H Kroenke; Carla M Prado; Marilyn L Kwan; Adrienne Castillo; Erin Weltzien; Elizabeth M Cespedes Feliciano; Jingjie Xiao; Bette J Caan Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-12-16 Impact factor: 4.254
Authors: Mehmet Asim Bilen; Dylan J Martini; Yuan Liu; Julie M Shabto; Jacqueline T Brown; Milton Williams; Amir I Khan; Alexandra Speak; Colleen Lewis; Hannah Collins; Haydn T Kissick; Bradley C Carthon; Mehmet Akce; Walid L Shaib; Olatunji B Alese; Rathi N Pillai; Conor E Steuer; Christina S Wu; David H Lawson; Ragini R Kudchadkar; Bassel F El-Rayes; Suresh S Ramalingam; Taofeek K Owonikoko; R Donald Harvey; Viraj A Master Journal: Oncologist Date: 2019-12-05