Literature DB >> 33633536

The Complexity of the cGAS-STING Pathway in CNS Pathologies.

Amelia L Fryer1, Amar Abdullah1, Juliet M Taylor1, Peter J Crack1.   

Abstract

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammation. As an upstream regulator of type-I IFNs, STING modulation presents a novel therapeutic opportunity to mediate inflammation in the CNS. This review will detail the current knowledge of protective and detrimental STING activity in acute and chronic CNS pathologies and the current therapeutic avenues being explored.
Copyright © 2021 Fryer, Abdullah, Taylor and Crack.

Entities:  

Keywords:  STING; cGAS; central nervous system; interferon; neuroinflammation

Year:  2021        PMID： 33633536      PMCID： PMC7900568          DOI： 10.3389/fnins.2021.621501

Source DB:  PubMed          Journal:  Front Neurosci        ISSN： 1662-453X            Impact factor:   4.677


  113 in total

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  8 in total

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