Tess D Pottinger1,2, Sadiya S Khan3,4, Yinan Zheng3, Wei Zhang3, Hilary A Tindle5,6, Matthew Allison7, Gretchen Wells8, Aladdin H Shadyab7, Rami Nassir9, Lisa Warsinger Martin10, JoAnn E Manson11, Donald M Lloyd-Jones3, Philip Greenland3, Andrea A Baccarelli12, Eric A Whitsel13,14, Lifang Hou3. 1. Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. tdp2117@cumc.columbia.edu. 2. Institute for Genomic Medicine, Columbia University, 701 West 168th Street, New York, NY, 10032, USA. tdp2117@cumc.columbia.edu. 3. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 4. Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 5. Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 6. Geriatric Research Education and Clinical Centers (GRECC), Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA. 7. Department of Family Medicine and Public Health, San Diego School of Medicine, University of California, La Jolla, CA, USA. 8. University of Kentucky, Lexington, KY, USA. 9. University of California Davis, Davis, CA, USA. 10. George Washington University, Washington, DC, USA. 11. Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 12. Columbia University, New York, NY, USA. 13. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. 14. Department of Medicine School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Abstract
BACKGROUND: Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the "Life's Simple 7" ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom from cardiovascular disease, the leading cause of death for women in the United States. DNA methylation markers of aging have been aggregated into a composite epigenetic age score, which is associated with cardiovascular morbidity and mortality. However, it is unknown whether poor CVH is associated with acceleration of aging as measured by DNA methylation markers in epigenetic age. METHODS AND RESULTS: We performed a cross-sectional analysis of racially/ethnically diverse post-menopausal women enrolled in the Women's Health Initiative cohort recruited between 1993 and 1998. Epigenetic age acceleration (EAA) was calculated using DNA methylation data on a subset of participants and the published Horvath and Hannum methods for intrinsic and extrinsic EAA. CVH was calculated using the AHA measures of CVH contributing to a 7-point score. We examined the association between CVH score and EAA using linear regression modeling adjusting for self-reported race/ethnicity and education. Among the 2,170 participants analyzed, 50% were white and mean age was 64 (7 SD) years. Higher or more favorable CVH scores were associated with lower extrinsic EAA (~ 6 months younger age per 1 point higher CVH score, p < 0.0001), and lower intrinsic EAA (3 months younger age per 1 point higher CVH score, p < 0.028). CONCLUSIONS: These cross-sectional observations suggest a possible mechanism by which ideal CVH is associated with greater longevity.
BACKGROUND: Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the "Life's Simple 7" ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom from cardiovascular disease, the leading cause of death for women in the United States. DNA methylation markers of aging have been aggregated into a composite epigenetic age score, which is associated with cardiovascular morbidity and mortality. However, it is unknown whether poor CVH is associated with acceleration of aging as measured by DNA methylation markers in epigenetic age. METHODS AND RESULTS: We performed a cross-sectional analysis of racially/ethnically diverse post-menopausal women enrolled in the Women's Health Initiative cohort recruited between 1993 and 1998. Epigenetic age acceleration (EAA) was calculated using DNA methylation data on a subset of participants and the published Horvath and Hannum methods for intrinsic and extrinsic EAA. CVH was calculated using the AHA measures of CVH contributing to a 7-point score. We examined the association between CVH score and EAA using linear regression modeling adjusting for self-reported race/ethnicity and education. Among the 2,170 participants analyzed, 50% were white and mean age was 64 (7 SD) years. Higher or more favorable CVH scores were associated with lower extrinsic EAA (~ 6 months younger age per 1 point higher CVH score, p < 0.0001), and lower intrinsic EAA (3 months younger age per 1 point higher CVH score, p < 0.028). CONCLUSIONS: These cross-sectional observations suggest a possible mechanism by which ideal CVH is associated with greater longevity.
Entities:
Keywords:
Cardiovascular health (CVH); DNA methylation; Epigenetic age acceleration; Simple seven; Women’s health initiative (WHI)
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