Zahra Hadian1, Ali Akbar Moghadamnia2, Sohrab Kazemi3, Atena Shirzad4. 1. Student Research Committee, Babol University of Medical Sciences, Babol, Iran. 2. Pharmacology & Toxicology, Neuroscience Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran. 3. Pharmaceutics Sciences, Neuroscience Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran. 4. Oral Medicine, Oral Health Research Center, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Abstract
OBJECTIVE: Recurrent aphthous stomatitis is one of the most common chronic inflammatory diseases in oral mucosa. Beneficial effects of omega-3 supplements on some inflammatory diseases have been proved. The aim of present study was to evaluate the effect of omega-3 supplements in recurrent aphthous stomatitis management and improve oral health-related quality of life. METHODS: In this double-blind clinical trial, 40 patients with minor recurrent aphthous stomatitis were randomly divided into case and control groups. The case group received 1000 mg capsules of omega-3, while the control group received placebo capsules for 6 months. The questionnaires of the ulcer severity score and the chronic oral mucosal disease questionnaire were filled by the patients in three steps, at the baseline session, after 3 months, and after 6 months. The data were analyzed by SPSS 22 software through ANOVA, Mann-Whitney, and chi-square tests. P < 0.05 was considered as significant. RESULTS: In the omega-3 group, the ulcer severity score showed significant reduction by three-month and six-month follow-ups (P < 0.0001, P < 0.0001, respectively). The mean score of the chronic oral mucosal disease questionnaire significantly improved by three-month and six-month follow-ups in the omega-3-receiving group. CONCLUSION: Use of omega-3 oral supplements decreased the severity of aphthous ulcer and improved oral health-related quality of life.
OBJECTIVE: Recurrent aphthous stomatitis is one of the most common chronic inflammatory diseases in oral mucosa. Beneficial effects of omega-3 supplements on some inflammatory diseases have been proved. The aim of present study was to evaluate the effect of omega-3 supplements in recurrent aphthous stomatitis management and improve oral health-related quality of life. METHODS: In this double-blind clinical trial, 40 patients with minor recurrent aphthous stomatitis were randomly divided into case and control groups. The case group received 1000 mg capsules of omega-3, while the control group received placebo capsules for 6 months. The questionnaires of the ulcer severity score and the chronic oral mucosal disease questionnaire were filled by the patients in three steps, at the baseline session, after 3 months, and after 6 months. The data were analyzed by SPSS 22 software through ANOVA, Mann-Whitney, and chi-square tests. P < 0.05 was considered as significant. RESULTS: In the omega-3 group, the ulcer severity score showed significant reduction by three-month and six-month follow-ups (P < 0.0001, P < 0.0001, respectively). The mean score of the chronic oral mucosal disease questionnaire significantly improved by three-month and six-month follow-ups in the omega-3-receiving group. CONCLUSION: Use of omega-3 oral supplements decreased the severity of aphthous ulcer and improved oral health-related quality of life.
Authors: Dinka Rees; Elizabeth A Miles; Tapati Banerjee; Solenne J Wells; Catherine E Roynette; Klaus Wj Wahle; Philip C Calder Journal: Am J Clin Nutr Date: 2006-02 Impact factor: 7.045
Authors: Timothy Trebble; Nigel K Arden; Mike A Stroud; Stephen A Wootton; Graham C Burdge; Elizabeth A Miles; Anne B Ballinger; Rachel L Thompson; Philip C Calder Journal: Br J Nutr Date: 2003-08 Impact factor: 3.718