Literature DB >> 33627627

Exosomes in ovarian cancer ascites promote epithelial-mesenchymal transition of ovarian cancer cells by delivery of miR-6780b-5p.

Jing Cai1, Lanqing Gong1, Guodong Li2, Jing Guo1, Xiaoqing Yi3, Zehua Wang4.   

Abstract

The poor prognosis of ovarian cancer is mainly due to metastasis, and the specific mechanism underlying ovarian cancer metastasis is not clear. Ascites-derived exosomes (ADEs) play an important role in the progression of ovarian cancer, but the mechanism is unknown. Here, we found that ADEs promoted ovarian cancer metastasis not only in vitro but also in vivo. This promotive function was based on epithelial-mesenchymal transition (EMT) of ovarian cancer cells. Bioinformatics analysis of RNA sequencing microarray data indicated that miR-6780b-5p may be the key microRNA (miRNA) in ADEs that facilitates cancer metastasis. Moreover, the expression of exosomal miR-6780b-5p correlated with tumor metastasis in ovarian cancer patients. miR-6780b-5p overexpression promoted and miR-6780b-5p downregulation suppressed EMT of ovarian cancer cells. These results suggest that ADEs transfer miR-6780b-5p to ovarian cancer cells, promoting EMT and finally facilitating ovarian cancer metastasis.

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Year:  2021        PMID： 33627627      PMCID： PMC7904844          DOI： 10.1038/s41419-021-03490-5

Source DB:  PubMed          Journal:  Cell Death Dis            Impact factor:   8.469


  53 in total

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Authors:  Clotilde Théry; Laurence Zitvogel; Sebastian Amigorena
Journal:  Nat Rev Immunol       Date:  2002-08       Impact factor: 53.106

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Authors:  Jieru Zhou; Xiaoduan Li; Xiaoli Wu; Ting Zhang; Qinyi Zhu; Xinjing Wang; Husheng Wang; Kai Wang; Yingying Lin; Xipeng Wang
Journal:  Cancer Immunol Res       Date:  2018-11-05       Impact factor: 11.151

Review 3.  Epithelial-mesenchymal transition in ovarian cancer.

Authors:  Daniele Vergara; Benjamin Merlot; Jean-Philippe Lucot; Pierre Collinet; Denis Vinatier; Isabelle Fournier; Michel Salzet
Journal:  Cancer Lett       Date:  2009-10-31       Impact factor: 8.679

4.  Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype.

Authors:  Xin Chen; Jieru Zhou; Xiaoduan Li; Xinjing Wang; Yingying Lin; Xipeng Wang
Journal:  Cancer Lett       Date:  2018-08-08       Impact factor: 8.679

5.  Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.

Authors:  Sonia A Melo; Hikaru Sugimoto; Joyce T O'Connell; Noritoshi Kato; Alberto Villanueva; August Vidal; Le Qiu; Edward Vitkin; Lev T Perelman; Carlos A Melo; Anthony Lucci; Cristina Ivan; George A Calin; Raghu Kalluri
Journal:  Cancer Cell       Date:  2014-10-23       Impact factor: 31.743

Review 6.  Mechanisms and Targets Involved in Dissemination of Ovarian Cancer.

Authors:  Ulrich H Weidle; Fabian Birzele; Gwendlyn Kollmorgen; Rüdiger Rueger
Journal:  Cancer Genomics Proteomics       Date:  2016 11-12       Impact factor: 4.069

7.  Exosomes in Human Breast Milk Promote EMT.

Authors:  Wenyi Qin; Yoshikazu Tsukasaki; Santanu Dasgupta; Nitai Mukhopadhyay; Mitsuo Ikebe; Edward R Sauter
Journal:  Clin Cancer Res       Date:  2016-04-08       Impact factor: 12.531

8.  KRAS-dependent sorting of miRNA to exosomes.

Authors:  Diana J Cha; Jeffrey L Franklin; Yongchao Dou; Qi Liu; James N Higginbotham; Michelle Demory Beckler; Alissa M Weaver; Kasey Vickers; Nirpesh Prasad; Shawn Levy; Bing Zhang; Robert J Coffey; James G Patton
Journal:  Elife       Date:  2015-07-01       Impact factor: 8.140

9.  High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells.

Authors:  Vanessa A Enriquez; Ellane R Cleys; Juliano C Da Silveira; Monique A Spillman; Quinton A Winger; Gerrit J Bouma
Journal:  Biomed Res Int       Date:  2015-10-25       Impact factor: 3.411

Review 10.  Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets.

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Journal:  Sci Rep       Date:  2018-06-15       Impact factor: 4.379
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Journal:  J Hematol Oncol       Date:  2022-06-28       Impact factor: 23.168

2.  Snail Promotes Cancer Cell Proliferation via Its Interaction with the BIRC3.

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Review 3.  Non-Coding RNAs Delivery by Small Extracellular Vesicles and Their Applications in Ovarian Cancer.

Authors:  Mu Liu; Xiaofang Zhou; Jie Tang
Journal:  Front Bioeng Biotechnol       Date:  2022-05-19

Review 4.  Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers.

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Review 5.  Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis.

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Journal:  Front Cell Dev Biol       Date:  2022-03-02

Review 6.  Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine.

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Journal:  Genes Dis       Date:  2022-03-01

Review 7.  Advances in Exosomes as Diagnostic and Therapeutic Biomarkers for Gynaecological Malignancies.

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8.  Cancer Three-Dimensional Spheroids Mimic In Vivo Tumor Features, Displaying "Inner" Extracellular Vesicles and Vasculogenic Mimicry.

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Review 9.  Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion.

Authors:  Wanjia Tian; Ningjing Lei; Junying Zhou; Mengyu Chen; Ruixia Guo; Bo Qin; Yong Li; Lei Chang
Journal:  Cell Death Dis       Date:  2022-01-18       Impact factor: 8.469

Review 10.  Salivary Exosomes: From Waste to Promising Periodontitis Treatment.

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  10 in total

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