Caihong Wu1, Xuehe Zhu1, Haipeng Ren1, Fuyong Tan2, Xudong Liu1. 1. Emergency Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China. 2. The Medical Examination Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China.
Abstract
OBJECTIVE: The purpose of this study was to clarify the value of intestinal fatty acid-binding protein (I-FABP) for the early diagnosis of strangulated intestinal obstruction through a meta-analysis. METHODS: A search was performed on PubMed, EBSCO, the Cochrane Library, the Web of Science, EMBASE, CNKI, and WanFang for studies on the diagnosis of strangulated intestinal obstruction based on I-FABP. Endnote X9 software and the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) were used to screen the studies and evaluate their quality, respectively. Meta-Disc 1.4 and Stata 15.1 software were used to perform the assessment of heterogeneity and meta-analysis. RESULT: A total of eight studies were included, Spearman correlation coefficient was 0.703 (P = 0.078), suggesting that there was no threshold effect. The pooled results of the meta-analysis were as follows: sensitivity: 0.75 (95% CI: 0.66-0.81), specificity: 0.83 (95% CI: 0.71-0.91), positive likelihood ratio (PLR): 4.35 (95% CI: 2.57-7.36), negative likelihood ratio (NLR): 0.31 (95% CI: 0.24-0.39), and diagnostic odds ratio (DOR): 14.19 (95% CI: 8.08-24.92). The area under the curve was 0.83. There was obvious heterogeneity among the studies. CONCLUSION: I-FABP is very valuable for the early diagnosis of strangulated intestinal obstruction and can be used to distinguish strangulated intestinal obstruction from intestinal obstruction in a timely manner, enabling accurate planning of the timing of surgery.
OBJECTIVE: The purpose of this study was to clarify the value of intestinal fatty acid-binding protein (I-FABP) for the early diagnosis of strangulated intestinal obstruction through a meta-analysis. METHODS: A search was performed on PubMed, EBSCO, the Cochrane Library, the Web of Science, EMBASE, CNKI, and WanFang for studies on the diagnosis of strangulated intestinal obstruction based on I-FABP. Endnote X9 software and the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) were used to screen the studies and evaluate their quality, respectively. Meta-Disc 1.4 and Stata 15.1 software were used to perform the assessment of heterogeneity and meta-analysis. RESULT: A total of eight studies were included, Spearman correlation coefficient was 0.703 (P = 0.078), suggesting that there was no threshold effect. The pooled results of the meta-analysis were as follows: sensitivity: 0.75 (95% CI: 0.66-0.81), specificity: 0.83 (95% CI: 0.71-0.91), positive likelihood ratio (PLR): 4.35 (95% CI: 2.57-7.36), negative likelihood ratio (NLR): 0.31 (95% CI: 0.24-0.39), and diagnostic odds ratio (DOR): 14.19 (95% CI: 8.08-24.92). The area under the curve was 0.83. There was obvious heterogeneity among the studies. CONCLUSION: I-FABP is very valuable for the early diagnosis of strangulated intestinal obstruction and can be used to distinguish strangulated intestinal obstruction from intestinal obstruction in a timely manner, enabling accurate planning of the timing of surgery.
Authors: Joep Grootjans; Kaatje Lenaerts; Wim A Buurman; Cornelis H C Dejong; Joep P M Derikx Journal: World J Gastroenterol Date: 2016-03-07 Impact factor: 5.742