Hui Shi1, Benyan Wu2, Jun Wan1, Wenhui Liu1, Binbin Su1. 1. Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing, China. 2. Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing, China. Electronic address: benyanwu@vip.sina.com.
Abstract
BACKGROUND AND OBJECTIVE: To evaluate the clinical usefulness of serum intestinal fatty acid binding protein (I-FABP) and D-lactate measurements in the early diagnosis of acute intestinal ischemia. METHODS: A total of 272 patients with a clinical diagnosis of acute abdomen were recruited for this trial over a 24-month period, and 37 healthy people were included in the study as controls. Serum I-FABP and D-lactate levels were measured by an enzyme-linked immunosorbent assay and compared in patients with intestinal ischemia vs. non-intestinal ischemia. RESULTS: Of the 272 patients, 39 were diagnosed with intestinal ischemia and 233 were diagnosed with other cause of acute abdomen. The mean serum I-FABP and D-lactate levels in the patients with intestinal ischemia were 149.74±57.81ng/mL and 52.73±26.46 ug/mL, respectively, and were significantly higher compared with patients with non-intestinal ischemia (36.78±11.25ng/mL and 15.58±5.17 ug/mL, respectively) and with levels in the healthy control group (8.33±6.25 ng/mL and 5.47±1.64 ug/mL, respectively). Area under the curve for I-FABP and D-lactate were 0.85 and 0.69, and cut-off values of 93.07 ng/mL and 34.28 ug/mL, respectively. CONCLUSION: Serum I-FABP and D-lactate can improve the diagnosis of intestinal ischemia in patients with acute abdomen who are at risk.
BACKGROUND AND OBJECTIVE: To evaluate the clinical usefulness of serum intestinal fatty acid binding protein (I-FABP) and D-lactate measurements in the early diagnosis of acute intestinal ischemia. METHODS: A total of 272 patients with a clinical diagnosis of acute abdomen were recruited for this trial over a 24-month period, and 37 healthy people were included in the study as controls. Serum I-FABP and D-lactate levels were measured by an enzyme-linked immunosorbent assay and compared in patients with intestinal ischemia vs. non-intestinal ischemia. RESULTS: Of the 272 patients, 39 were diagnosed with intestinal ischemia and 233 were diagnosed with other cause of acute abdomen. The mean serum I-FABP and D-lactate levels in the patients with intestinal ischemia were 149.74±57.81ng/mL and 52.73±26.46 ug/mL, respectively, and were significantly higher compared with patients with non-intestinal ischemia (36.78±11.25ng/mL and 15.58±5.17 ug/mL, respectively) and with levels in the healthy control group (8.33±6.25 ng/mL and 5.47±1.64 ug/mL, respectively). Area under the curve for I-FABP and D-lactate were 0.85 and 0.69, and cut-off values of 93.07 ng/mL and 34.28 ug/mL, respectively. CONCLUSION: Serum I-FABP and D-lactate can improve the diagnosis of intestinal ischemia in patients with acute abdomen who are at risk.
Authors: I Djordjevic; K Eghbalzadeh; S Heinen; G Schlachtenberger; S Gerfer; A Sabashnikov; J Merkle; C Weber; E Kuhn; M Zeriouh; P Rahmanian; N Mader; O-J Liakopoulos; T Wahlers Journal: World J Surg Date: 2020-01 Impact factor: 3.352
Authors: Fausto Catena; Salomone Di Saverio; Federico Coccolini; Luca Ansaloni; Belinda De Simone; Massimo Sartelli; Harry Van Goor Journal: World J Gastrointest Surg Date: 2016-03-27
Authors: Andrew S Miller; Kathryn Boyce; Benjamin Box; Matthew D Clarke; Sarah E Duff; Niamh M Foley; Richard J Guy; Lisa H Massey; George Ramsay; Dominic A J Slade; James A Stephenson; Phil J Tozer; Danette Wright Journal: Colorectal Dis Date: 2021-02 Impact factor: 3.917