Literature DB >> 33622490

Bedaquiline as Treatment for Disseminated Nontuberculous Mycobacteria Infection in 2 Patients Co-Infected with HIV.

Eliza Gil, Nicola Sweeney, Veronica Barrett, Stephen Morris-Jones, Robert F Miller, Victoria J Johnston, Michael Brown.   

Abstract

Nontuberculous mycobacteria can cause disseminated infections in immunocompromised patients and are challenging to treat because of antimicrobial resistance and adverse effects of prolonged multidrug treatment. We report successful treatment with bedaquiline, a novel antimycobacterial drug, as part of combination therapy for 2 patients with disseminated nontuberculous mycobacteria co-infected with HIV.

Entities:  

Keywords:  18fluorodeoxyglucose-positron emission tomography/computed tomography imaging; HIV; Mycobacteriaceae; Mycobacterium; Mycobacterium abscessus; Mycobacterium avium; NTM; antibacterial drugs; antiinfective drugs; antimicrobial resistance; antitubercular drugs; bacteria; bedaquiline; co-infection; nontuberculous mycobacteria; respiratory infections; tuberculosis and other mycobacteria; viruses

Mesh：

Substances：

Year:  2021        PMID： 33622490      PMCID： PMC7920675          DOI： 10.3201/eid2703.202359

Source DB:  PubMed          Journal:  Emerg Infect Dis        ISSN： 1080-6040            Impact factor:   6.883


  14 in total

Review 1.  Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.

Authors:  Barbara A Brown-Elliott; Kevin A Nash; Richard J Wallace
Journal:  Clin Microbiol Rev       Date:  2012-07       Impact factor: 26.132

2.  ATP synthase inhibition of Mycobacterium avium is not bactericidal.

Authors:  Nacer Lounis; Tom Gevers; Joke Van den Berg; Luc Vranckx; Koen Andries
Journal:  Antimicrob Agents Chemother       Date:  2009-09-08       Impact factor: 5.191

Review 3.  Antimycobacterial strategies to evade antimicrobial resistance in the nontuberculous mycobacteria.

Authors:  Beverley Cherie Millar; John Edmund Moore
Journal:  Int J Mycobacteriol       Date:  2019 Jan-Mar

4.  Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease.

Authors:  David C Alexander; Ravikiran Vasireddy; Sruthi Vasireddy; Julie V Philley; Barbara A Brown-Elliott; Benjamin J Perry; David E Griffith; Jeana L Benwill; Andrew D S Cameron; Richard J Wallace
Journal:  J Clin Microbiol       Date:  2016-12-07       Impact factor: 5.948

5.  Minimum inhibitory concentration distributions for Mycobacterium avium complex-towards evidence-based susceptibility breakpoints.

Authors:  Thomas Schön; Erja Chryssanthou
Journal:  Int J Infect Dis       Date:  2017-01-06       Impact factor: 3.623

6.  Multidrug-resistant tuberculosis and culture conversion with bedaquiline.

Authors:  Andreas H Diacon; Alexander Pym; Martin P Grobusch; Jorge M de los Rios; Eduardo Gotuzzo; Irina Vasilyeva; Vaira Leimane; Koen Andries; Nyasha Bakare; Tine De Marez; Myriam Haxaire-Theeuwes; Nacer Lounis; Paul Meyvisch; Els De Paepe; Rolf P G van Heeswijk; Brian Dannemann
Journal:  N Engl J Med       Date:  2014-08-21       Impact factor: 91.245

Review 7.  Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline.

Authors:  Moloko C Cholo; Maborwa T Mothiba; Bernard Fourie; Ronald Anderson
Journal:  J Antimicrob Chemother       Date:  2016-10-20       Impact factor: 5.790

8.  In vitro activity of bedaquiline against slow-growing nontuberculous mycobacteria.

Authors:  Anandi Martin; Isabel Torres Godino; Diana Angelica Aguilar-Ayala; Vanessa Mathys; Nacer Lounis; Hector Rodriguez Villalobos
Journal:  J Med Microbiol       Date:  2019-06-18       Impact factor: 2.472

9.  A bedaquiline/clofazimine combination regimen might add activity to the treatment of clinically relevant non-tuberculous mycobacteria.

Authors:  Mike Marvin Ruth; Jasper J N Sangen; Karlijn Remmers; Lian J Pennings; Elin Svensson; Rob E Aarnoutse; Sanne M H Zweijpfenning; Wouter Hoefsloot; Saskia Kuipers; Cecile Magis-Escurra; Heiman F L Wertheim; Jakko van Ingen
Journal:  J Antimicrob Chemother       Date:  2019-04-01       Impact factor: 5.790

10.  In vitro activity of bedaquiline against rapidly growing nontuberculous mycobacteria.

Authors:  Diana A Aguilar-Ayala; Margo Cnockaert; Emmanuel André; Koen Andries; Jorge A Gonzalez-Y-Merchand; Peter Vandamme; Juan Carlos Palomino; Anandi Martin
Journal:  J Med Microbiol       Date:  2017-07-28       Impact factor: 2.472
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  2 in total

Review 1.  Pharmacologic Management of Mycobacterium chimaera Infections: A Primer for Clinicians.

Authors:  Matt Mason; Eric Gregory; Keith Foster; Megan Klatt; Sara Zoubek; Albert J Eid
Journal:  Open Forum Infect Dis       Date:  2022-06-15       Impact factor: 4.423

Review 2.  Nontuberculous Mycobacteria Lung Disease (NTM-LD): Current Recommendations on Diagnosis, Treatment, and Patient Management.

Authors:  Kriti Pathak; Stephanie Hart; Leah Lande
Journal:  Int J Gen Med       Date:  2022-10-01
  2 in total

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