Literature DB >> 33614946

Chirality in Cannabinoid Research.

Crist N Filer1.   

Abstract

Mankind has long utilized Cannabis for diverse purposes. However, it has only been since the late 19th century that its individual cannabinoids began to be isolated, analyzed, and synthesized. By the mid-20th century it was discovered that many cannabinoids were asymmetric, with chirality often controlling their pharmacology. Increasingly accurate measurement and understanding of cannabinoid chirality will facilitate their synthesis and accelerate their medicinal applications. Copyright 2021, Mary Ann Liebert, Inc., publishers.

Entities:  

Keywords:  MicroED; cannabinoid; cannabis; chiral HPLC

Mesh:

Substances:

Year:  2021        PMID: 33614946      PMCID: PMC7891190          DOI: 10.1089/can.2020.0027

Source DB:  PubMed          Journal:  Cannabis Cannabinoid Res        ISSN: 2378-8763


  16 in total

1.  The crystal and molecular structure of delta-9-tetrahydrocannabinolic acid b.

Authors:  E Rosenqvist; T Ottersen
Journal:  Acta Chem Scand B       Date:  1975

Review 2.  Microcrystal Electron Diffraction (MicroED) for Small-Molecule Structure Determination.

Authors:  Tom Kunde; Bernd M Schmidt
Journal:  Angew Chem Int Ed Engl       Date:  2018-12-12       Impact factor: 15.336

3.  Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography.

Authors:  G Mazzoccanti; O H Ismail; I D'Acquarica; C Villani; C Manzo; M Wilcox; A Cavazzini; F Gasparrini
Journal:  Chem Commun (Camb)       Date:  2017-11-14       Impact factor: 6.222

4.  The absolute configuration of delta-1-tetrahydrocannabinol, the major active constituent of hashish.

Authors:  R Mechoulam; Y Gaoni
Journal:  Tetrahedron Lett       Date:  1967-03       Impact factor: 2.415

5.  Hashish. I. The structure of cannabidiol.

Authors:  R Mechoulam; Y Shvo
Journal:  Tetrahedron       Date:  1963-12       Impact factor: 2.457

Review 6.  Chemical constituents of marijuana: the complex mixture of natural cannabinoids.

Authors:  Mahmoud A Elsohly; Desmond Slade
Journal:  Life Sci       Date:  2005-09-30       Impact factor: 5.037

7.  Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors.

Authors:  Lumír O Hanus; Susanna Tchilibon; Datta E Ponde; Aviva Breuer; Ester Fride; Raphael Mechoulam
Journal:  Org Biomol Chem       Date:  2005-02-16       Impact factor: 3.876

8.  A stereospecific synthesis of (-)-delta 1- and (-)-delta 1(6)-tetrahydrocannabinols.

Authors:  R Mechoulam; P Braun; Y Gaoni
Journal:  J Am Chem Soc       Date:  1967-08-16       Impact factor: 15.419

9.  Characterization of the synthetic cannabinoid MDMB-CHMCZCA.

Authors:  Carina Weber; Stefan Pusch; Dieter Schollmeyer; Sascha Münster-Müller; Michael Pütz; Till Opatz
Journal:  Beilstein J Org Chem       Date:  2016-12-21       Impact factor: 2.883

Review 10.  Instrumentation for Vibrational Circular Dichroism Spectroscopy: Method Comparison and Newer Developments.

Authors:  Timothy A Keiderling
Journal:  Molecules       Date:  2018-09-19       Impact factor: 4.411

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