Ahmed E M Shehata1, Siva P Kambhampati2, Jiangxia Wang3, Uri S Soiberman1. 1. Cornea Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2. Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3. Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Abstract
PURPOSE: This study aims to measure burst pressures in 3 mm clear corneal incisions sealed with ReSure, a biodegradable hydrogel sealant, and to compare it to traditional 10-0 nylon sutures and unsealed controls. DESIGN: An ex vivo animal study. METHODS: 3 mm clear corneal incisions were performed in rabbit eyes (ex vivo). The burst pressure was determined, and then, the incisions were sealed with either ReSure glue or a single 10-0 nylon suture. Burst pressure measurements were repeated. RESULTS: Fourteen eyes were included. The median burst pressure in the suture-control group (7 eyes) prior to suture application was 7 mmHg (range: 0-45); the median burst pressure in the 7 glue-controls was 36 mmHg (range: 5-61, p = 0.08 for the comparison of the two control groups). The median burst pressure in the glue group was 93 mmHg (range: 39-129, p = 0.043 when compared to glue-control). The median burst pressure in the suture group was 158 mmHg (range: 70-180, p = 0.018 when compared to suture-control). There was no statistically significant difference in burst pressure values between the glue and suture groups (p = 0.08). CONCLUSION: In this study, ReSure glue applied to 3 mm clear corneal incisions provided sufficient resistance to elevated intraocular pressure when compared to controls. The results of this study suggest that ReSure glue may be comparable to a single 10-0 nylon suture in resisting fluid egress during the early postoperative period.
PURPOSE: This study aims to measure burst pressures in 3 mm clear corneal incisions sealed with ReSure, a biodegradable hydrogel sealant, and to compare it to traditional 10-0 nylon sutures and unsealed controls. DESIGN: An ex vivo animal study. METHODS: 3 mm clear corneal incisions were performed in rabbit eyes (ex vivo). The burst pressure was determined, and then, the incisions were sealed with either ReSure glue or a single 10-0 nylon suture. Burst pressure measurements were repeated. RESULTS: Fourteen eyes were included. The median burst pressure in the suture-control group (7 eyes) prior to suture application was 7 mmHg (range: 0-45); the median burst pressure in the 7 glue-controls was 36 mmHg (range: 5-61, p = 0.08 for the comparison of the two control groups). The median burst pressure in the glue group was 93 mmHg (range: 39-129, p = 0.043 when compared to glue-control). The median burst pressure in the suture group was 158 mmHg (range: 70-180, p = 0.018 when compared to suture-control). There was no statistically significant difference in burst pressure values between the glue and suture groups (p = 0.08). CONCLUSION: In this study, ReSure glue applied to 3 mm clear corneal incisions provided sufficient resistance to elevated intraocular pressure when compared to controls. The results of this study suggest that ReSure glue may be comparable to a single 10-0 nylon suture in resisting fluid egress during the early postoperative period.
Authors: Samuel Masket; John A Hovanesian; Jeffrey Levenson; Farrell Tyson; William Flynn; Michael Endl; Parag A Majmudar; Satish Modi; Ralph Chu; Michael B Raizman; Stephen S Lane; Terry Kim Journal: J Cataract Refract Surg Date: 2014-11-24 Impact factor: 3.351
Authors: Nambi Nallasamy; Karen E Grove; Gary L Legault; Melissa B Daluvoy; Terry Kim Journal: J Cataract Refract Surg Date: 2017-08 Impact factor: 3.351