Literature DB >> 3361127

Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig.

D Kvale1, D Løvhaug, L M Sollid, P Brandtzaeg.   

Abstract

Secretory component (SC) is the receptor that facilitates transcytosis of polymeric IgA and polymeric IgM through secretory epithelial cells and into exocrine fluids. The present study showed that rTNF-alpha enhanced the cellular pool, membrane expression, and secretion of functionally SC in a human colonic carcinoma cell line (HT-29m2) which is known to express and process SC like normal glandular cells. TNF-alpha also up-regulated membrane expression of the constitutive HLA class I molecules, whereas the cells remained HLA class II-negative.

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Year:  1988        PMID： 3361127

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  40 in total

Review 1.  A role for epithelial gamma delta T cells in tissue repair.

Authors:  D A Witherden; S E Rieder; R Boismenu; W L Havran
Journal:  Springer Semin Immunopathol       Date:  2000

2.  The distribution of immunoreactive interferon-gamma-containing cells in normal human tissues.

Authors:  F Brett; A Mowat; M A Farquharson; M McGill; C Hind; J Richmond; D Murray; N U Khan; A K Foulis
Journal:  Immunology       Date:  1992-12       Impact factor: 7.397

3.  Reduced expression of polymeric immunoglobulin receptor (pIgR) in nasopharyngeal carcinoma and its correlation with prognosis.

Authors:  Xuanchang Qi; Xuechang Li; Xiuxia Sun
Journal:  Tumour Biol       Date:  2016-02-24

4.  Secretory IgA in saliva can be a useful stress marker.

Authors:  S Tsujita; K Morimoto
Journal:  Environ Health Prev Med       Date:  1999-04       Impact factor: 3.674

Review 5.  A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity.

Authors:  K Fujihashi; M N Kweon; H Kiyono; J L VanCott; F W van Ginkel; M Yamamoto; J R McGhee
Journal:  Springer Semin Immunopathol       Date:  1997

Review 6.  Lymphoepithelial interactions in the mucosal immune system.

Authors:  P Brandtzaeg; L M Sollid; P S Thrane; D Kvale; K Bjerke; H Scott; K Kett; T O Rognum
Journal:  Gut       Date:  1988-08       Impact factor: 23.059

7.  Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa.

Authors:  K Valnes; H S Huitfeldt; P Brandtzaeg
Journal:  Gut       Date:  1990-06       Impact factor: 23.059

8.  Measurement of interleukin 10 in bronchoalveolar lavage from preterm ventilated infants.

Authors:  J R McColm; B J Stenson; N Biermasz; N McIntosh
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2000-03       Impact factor: 5.747

9.  The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.

Authors:  C S Kaetzel; J K Robinson; K R Chintalacharuvu; J P Vaerman; M E Lamm
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

10.  Ontogenesis of the secretory immune system and innate defence factors in human parotid glands.

Authors:  P S Thrane; T O Rognum; P Brandtzaeg
Journal:  Clin Exp Immunol       Date:  1991-11       Impact factor: 4.330
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