Hae-Won Shin1, Hyun Joo Cho2, Sang Wook Lee3, Hitoshi Shitara4, Mark Hallett5. 1. Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Chung-Ang University College of Medicine, Seoul, South Korea. 2. Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, University of Pittsburg Medical Center, Altoona, PA, USA. 3. Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD, USA; Department of Biomedical Engineering, Catholic University of America, Washington, DC, USA; Center for Applied Biomechanics and Rehabilitation Research, MedStar National Rehabilitation Hospital, Washington, DC, USA; Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea. 4. Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD, USA; Department of Orthopedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. 5. Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD, USA. Electronic address: hallettm@ninds.nih.gov.
Abstract
INTRODUCTION: Although sensory tricks are well known as the maneuvers that temporarily relieve dystonic symptoms in patients with cervical dystonia (CD), the underlying neurophysiological mechanisms remain unclear. We aimed to investigate brain potentials related to sensory tricks in patients with CD. METHODS: Thirteen patients with CD and 13 age-matched healthy volunteers participated. The experiment consisted of three conditions (moving the neck, moving an arm, and performing sensory tricks) presented in different blocks in random order in a contingent negative variation (CNV) paradigm. Warning and trigger stimuli (S1 and S2) were presented to the participants, who were instructed to prepare to perform the specific task for each condition after S1, and then to perform the task after S2. Early and late components of the CNV were measured. RESULTS: The late CNVs in patients with CD were significantly larger than those in healthy participants in Fz, FCz, Cz, and C3 electrodes. Only in patients with CD, the late CNVs were significantly greater for the 'sensory tricks' condition compared to the 'move neck' condition in Fz and C3 electrodes. CONCLUSION: The late CNV is increased during sensory tricks in patients with CD, suggesting that sensory tricks may affect mechanisms related to the motor preparatory phase in the premotor and primary motor areas. Sensory tricks may normalize impaired motor preparation in dystonia, leading to improved dystonic symptoms. Published by Elsevier Ltd.
INTRODUCTION: Although sensory tricks are well known as the maneuvers that temporarily relieve dystonic symptoms in patients with cervical dystonia (CD), the underlying neurophysiological mechanisms remain unclear. We aimed to investigate brain potentials related to sensory tricks in patients with CD. METHODS: Thirteen patients with CD and 13 age-matched healthy volunteers participated. The experiment consisted of three conditions (moving the neck, moving an arm, and performing sensory tricks) presented in different blocks in random order in a contingent negative variation (CNV) paradigm. Warning and trigger stimuli (S1 and S2) were presented to the participants, who were instructed to prepare to perform the specific task for each condition after S1, and then to perform the task after S2. Early and late components of the CNV were measured. RESULTS: The late CNVs in patients with CD were significantly larger than those in healthy participants in Fz, FCz, Cz, and C3 electrodes. Only in patients with CD, the late CNVs were significantly greater for the 'sensory tricks' condition compared to the 'move neck' condition in Fz and C3 electrodes. CONCLUSION: The late CNV is increased during sensory tricks in patients with CD, suggesting that sensory tricks may affect mechanisms related to the motor preparatory phase in the premotor and primary motor areas. Sensory tricks may normalize impaired motor preparation in dystonia, leading to improved dystonic symptoms. Published by Elsevier Ltd.
Entities:
Keywords:
Cervical dystonia; Contingent negative variation; Movement related potentials; Sensory tricks
Authors: R Kaji; A Ikeda; T Ikeda; T Kubori; T Mezaki; N Kohara; M Kanda; T Nagamine; M Honda; J C Rothwell Journal: Brain Date: 1995-04 Impact factor: 13.501