Fangxiang Mu1, Minge Shi2, Li Huang3, Dafen Wang4, Aiqun Shen5. 1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University. 2. Department of Obstetrics and Gynecology, Chongqing People's Hospital (Tongliang District). 3. Department of Obstetrics and Gynecology, Chongqing Maternal and Child Health Hospital (Shapingba District). 4. Department of Obstetrics and Gynecology, Chongqing People's Hospital (Bishan District). 5. Department of Obstetrics and Gynecology, Tongji Hospital Affiliated to Tongji University, Shanghai, PR China.
Abstract
OBJECTIVE: To identify the role of estrogen receptor-beta (ER-β) gene +1730G/A (rs4986938) polymorphisms in recurrent pregnancy loss (RPL). METHODS: All relevant case-control studies will be systematically searched in multiple databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet (CNKI), Wanfang and Cqvip. Both pooled odds rations (ORs) and 95% confidence intervals (CIs) will be used to assess the association between ER-β gene +1730G/A polymorphisms and RPL risk. The publication bias will be evaluated using Egger test. RESULTS: ER-β gene +1730G/A variation may be associated with a higher risk of RPL in Caucasian population. CONCLUSIONS: The findings of this meta-analysis will provide high-quality evidence for the association between ER-β gene +1730G/A polymorphisms and RPL, facilitating clinical practice and further scientific studies. OSF REGISTRATION NUMBER: 10.17605/OSF.IO/EW9FB.
OBJECTIVE: To identify the role of estrogen receptor-beta (ER-β) gene +1730G/A (rs4986938) polymorphisms in recurrent pregnancy loss (RPL). METHODS: All relevant case-control studies will be systematically searched in multiple databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet (CNKI), Wanfang and Cqvip. Both pooled odds rations (ORs) and 95% confidence intervals (CIs) will be used to assess the association between ER-β gene +1730G/A polymorphisms and RPL risk. The publication bias will be evaluated using Egger test. RESULTS: ER-β gene +1730G/A variation may be associated with a higher risk of RPL in Caucasian population. CONCLUSIONS: The findings of this meta-analysis will provide high-quality evidence for the association between ER-β gene +1730G/A polymorphisms and RPL, facilitating clinical practice and further scientific studies. OSF REGISTRATION NUMBER: 10.17605/OSF.IO/EW9FB.
Authors: Jin Ju Kim; Young Min Choi; Seon Ha Choung; Sang Ho Yoon; Gyoung Hoon Lee; Shin Yong Moon Journal: Fertil Steril Date: 2009-01-30 Impact factor: 7.329