OBJECTIVE: To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS). DESIGN: Case-control study. SETTING: University Department of Obstetrics and Gynecology. PATIENT(S): Women with (n = 138) or without (n = 290) PCOS. INTERVENTION(S): Genotyping was performed by polymerase chain reaction-restriction fragment-length polymorphism analysis. MAIN OUTCOME MEASURE(S): Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene. RESULT(S): There was a significant difference in the genotype distribution between the patients with PCOS and controls (non-GG rates were 22.1% for patients with PCOS and 36.6% for controls). There was also a significant difference in the G and A allele frequencies between these two groups (11.7% in patients vs. 19.1% in controls with A allele). But in patients with PCOS there were no significant differences in the serum levels of hormones, biochemical variables, or ovarian morphology between GG and non-GG genotypes. CONCLUSION(S): The ER-beta gene +1730 G/A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS). DESIGN: Case-control study. SETTING: University Department of Obstetrics and Gynecology. PATIENT(S): Women with (n = 138) or without (n = 290) PCOS. INTERVENTION(S): Genotyping was performed by polymerase chain reaction-restriction fragment-length polymorphism analysis. MAIN OUTCOME MEASURE(S): Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene. RESULT(S): There was a significant difference in the genotype distribution between the patients with PCOS and controls (non-GG rates were 22.1% for patients with PCOS and 36.6% for controls). There was also a significant difference in the G and A allele frequencies between these two groups (11.7% in patients vs. 19.1% in controls with A allele). But in patients with PCOS there were no significant differences in the serum levels of hormones, biochemical variables, or ovarian morphology between GG and non-GG genotypes. CONCLUSION(S): The ER-beta gene +1730 G/A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: Qi Zhao; Joseph H Lee; Deborah Pang; Alexis Temkin; Naeun Park; Sarah C Janicki; Warren B Zigman; Wayne Silverman; Benjamin Tycko; Nicole Schupf Journal: Dement Geriatr Cogn Disord Date: 2011-12-08 Impact factor: 2.959