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Literature DB >> 33606018

The Complement Pathway Is Activated in People With Human Immunodeficiency Virus and Is Associated With Non-AIDS Comorbidities.

Ivan Vujkovic-Cvijin¹, Ornella Sortino^2,3, Eveline Verheij⁴, Ferdinand W Wit⁴, Neeltje A Kootstra⁵, Brian Sellers⁶, Maarten Schim van der Loeff⁷, Yasmine Belkaid^1,6, Peter Reiss⁴, Irini Sereti³.

Abstract

Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers. Published by Oxford University Press for the Infectious Diseases Society of America 2021.

Entities: Chemical

Keywords: HIV; biomarker; comorbidities; complement; noncommunicable diseases

Mesh：

Substances：

Year: 2021 PMID： 33606018 PMCID： PMC8682793 DOI： 10.1093/infdis/jiab096

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

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