Sissel Jennifer Moltu1, Jiri Bronsky, Nicholas Embleton, Konstantinos Gerasimidis, Flavia Indrio, Jutta Köglmeier, Barbara de Koning, Alexandre Lapillonne, Lorenzo Norsa, Elvira Verduci, Magnus Domellöf. 1. Department of Neonatal Intensive Care, Oslo University Hospital, Norway Department of Paediatrics, University Hospital Motol, Prague, Czech Republic Newcastle Neonatal Service, Newcastle Hospitals NHS Trust and Newcastle University, Newcastle upon Tyne, UK Human Nutrition, School of Medicine, Dentistry and Nursing, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Glasgow, UK Department of Medical and Surgical Sciences, University of Foggia, Italy Department of paediatric Gastroenterology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK Paediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherland Paris University, APHP Necker-Enfants Malades hospital, Paris, France and CNRC, Baylor College of Medicine, Houston, Texas Paediatreic Hepatology Gastroenterology and Transplantation, ASST Papa Giovanni XXIIII, Bergamo, Italy Department of Health Sciences, University of Milan; Department of Paediatrics, Ospedale dei Bambini Vittore Buzzi Milan, Italy Department of Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden.
Abstract
OBJECTIVES: The nutritional management of critically ill term neonates and preterm infants varies widely, and controversies exist in regard to when to initiate nutrition, mode of feeding, energy requirements, and composition of enteral and parenteral feeds. Recommendations for nutritional support in critical illness are needed. METHODS: The ESPGHAN Committee on Nutrition (ESPGHAN-CoN) conducted a systematic literature search on nutritional support in critically ill neonates, including studies on basic metabolism. The Medline database and the Cochrane Library were used in the search for relevant publications. The quality of evidence was reviewed and discussed before voting on recommendations, and a consensus of 90% or more was required for the final approval. Important research gaps were also identified. RESULTS: This position paper provides clinical recommendations on nutritional support during different phases of critical illness in preterm and term neonates based on available literature and expert opinion. CONCLUSION: Basic research along with adequately powered trials are urgently needed to resolve key uncertainties on metabolism and nutrient requirements in this heterogeneous patient population.
OBJECTIVES: The nutritional management of critically ill term neonates and preterm infants varies widely, and controversies exist in regard to when to initiate nutrition, mode of feeding, energy requirements, and composition of enteral and parenteral feeds. Recommendations for nutritional support in critical illness are needed. METHODS: The ESPGHAN Committee on Nutrition (ESPGHAN-CoN) conducted a systematic literature search on nutritional support in critically ill neonates, including studies on basic metabolism. The Medline database and the Cochrane Library were used in the search for relevant publications. The quality of evidence was reviewed and discussed before voting on recommendations, and a consensus of 90% or more was required for the final approval. Important research gaps were also identified. RESULTS: This position paper provides clinical recommendations on nutritional support during different phases of critical illness in preterm and term neonates based on available literature and expert opinion. CONCLUSION: Basic research along with adequately powered trials are urgently needed to resolve key uncertainties on metabolism and nutrient requirements in this heterogeneous patient population.
Authors: Roland N Dickerson; Angela L Bingham; Todd W Canada; Lingtak Neander Chan; M Petrea Cober; Sarah V Cogle; Anne M Tucker; Vanessa J Kumpf Journal: Hosp Pharm Date: 2022-06-04
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Authors: Nuria Esturau-Escofet; Eduardo Rodríguez de San Miguel; Marcela Vela-Amieva; Martha E García-Aguilera; Circe C Hernández-Espino; Luis Macias-Kauffer; Carlos López-Candiani; José J Naveja; Isabel Ibarra-González Journal: Metabolites Date: 2022-03-17