| Literature DB >> 33604287 |
Yanyan Tang1,2,3, Rui Tang1,2,4,5, Mengtian Tang1,2,5, Ping Huang1,2, Zhiqiang Liao1,2, Jumei Zhou1,2, Lianqing Zhou1, Min Su1,3, Pan Chen1,3, Jiarui Jiang1,2, Yingbin Hu1,2, Yujuan Zhou1, QianJin Liao1,3, Zhaoyang Zeng1,6, Wei Xiong1,6, Junhong Chen1,2,5, Shaolin Nie1,2.
Abstract
Colorectal cancer (CRC) is one of the most common cancers worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in tumorigenesis and the development of CRC. By constructing a differential lncRNA expression profile, we screened gene chips and found that DNAJC3-AS1 was highly expressed in CRC tissues and was associated with poor prognosis in patients with CRC. Further, we proved through assays such as wound healing, colony formation, and Cell Counting Kit-8 (CCK8) that interfering with DNAJC3-AS1 could reduce the proliferation, migration, and invasion of CRC cells. Mechanically, we found that DNAJC3-AS1 regulates fatty acid synthase to promote the progression of CRC via the epidermal growth factor receptor/phosphatidylinositol 3-kinase/protein kinase B/nuclear factor κB signaling pathway. Therefore, DNAJC3-AS1 may be a new target for the diagnosis and therapy of CRC.Entities:
Keywords: DNAJC3-AS1; colorectal cancer; epidermal growth factor receptor pathway; fatty acid synthase; long non-coding RNA
Year: 2021 PMID： 33604287 PMCID： PMC7885865 DOI： 10.3389/fonc.2020.604534
Source DB: PubMed Journal: Front Oncol ISSN： 2234-943X Impact factor: 6.244