| Literature DB >> 33600493 |
Qingtang Shen1,2, Yifan E Wang2, Mathew Truong2, Kohila Mahadevan2, Jingze J Wu2, Hui Zhang2, Jiawei Li1, Harrison W Smith2, Craig A Smibert2, Alexander F Palazzo2.
Abstract
Mutations in RanBP2 (also known as Nup358), one of the main components of the cytoplasmic filaments of the nuclear pore complex, contribute to the overproduction of acute necrotizing encephalopathy (ANE1)-associated cytokines. Here we report that RanBP2 represses the translation of the interleukin 6 (IL6) mRNA, which encodes a cytokine that is aberrantly up-regulated in ANE1. Our data indicates that soon after its production, the IL6 messenger ribonucleoprotein (mRNP) recruits Argonautes bound to let-7 microRNA. After this mRNP is exported to the cytosol, RanBP2 sumoylates mRNP-associated Argonautes, thereby stabilizing them and enforcing mRNA silencing. Collectively, these results support a model whereby RanBP2 promotes an mRNP remodelling event that is critical for the miRNA-mediated suppression of clinically relevant mRNAs, such as IL6.Entities:
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Year: 2021 PMID： 33600493 PMCID： PMC7924746 DOI： 10.1371/journal.pgen.1009378
Source DB: PubMed Journal: PLoS Genet ISSN： 1553-7390 Impact factor: 5.917