Neuronal activity in the contralateral medial vestibular nucleus of the guinea pig following unilateral labyrinthectomy.

The recovery of normal ocular motor and postural behavior following unilateral labyrinthectomy is termed vestibular compensation and it has been attributed to the return of normal resting activity to neurons in the bilateral vestibular nuclei. Previous studies in the cat have reported that approximately normal resting activity returns to type I neurons in the medial vestibular nucleus (MVN) contralateral to the deafferentiation by 4-8 weeks post-operation (post-op.), while the gain of the response of these neurons to horizontal angular acceleration remains lower than normal. The present data demonstrate that, in the guinea pig, normal resting activity returns to the contralateral MVN type I neurons by only 52-60 h post-op., while the gain and phase of the response of these neurons to horizontal sinusoidal acceleration remains abnormal up to 8-12 months post-op. By contrast with previous studies, the present data show that type II neurons in the contralateral MVN exhibit some increase in their frequency of occurrence and gain toward normal values during vestibular compensation (at 52-60 h and 8-12 months post-op.). The rapid recovery of normal type I resting activity correlates with the disappearance of spontaneous nystagmus and postural asymmetries in the guinea pig by 52 h post-op.