Kátia Josiany Segheto1, Leidjaira Lopes Juvanhol2, Danielle Cristina Guimarães da Silva3, Cristiane Junqueira de Carvalho4, Fernanda Hansen5, Mariana Papini Gabiatti5, Adriana Maria Kakehasi6, Giana Zarbato Longo5. 1. Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Avenida PH Rolfs, s/n, Viçosa, Minas Gerais, 36571-000, Brasil. kaseghetto@gmail.com. 2. Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Avenida PH Rolfs, s/n, Viçosa, Minas Gerais, 36571-000, Brasil. 3. Centro de Ciências Biológicas e da Saúde, Universidade Federal do Oeste da Bahia, Bahia, 47808-021, Barreiras, Brasil. 4. Departamento de Medicina e Enfermagem, Universidade Federal de Viçosa, Avenida PH Rolfs, s/n, Viçosa, Minas Gerais, 36571-000, Brasil. 5. Departamento de Nutrição, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, 88040-900, Florianópolis, Santa Catarina, Brasil. 6. Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, n. 190, Santa Efigênia, Belo Horizonte, Minas Gerais, 30130-100, Brasil.
Abstract
Skin color has been indicated as an important factor in determining serum concentrations of 25-hydroxyvitamin D [25(OH)D], and consequently bone health. However, studies are controversial and scarce for mixed populations. PURPOSE/ INTRODUCTION: To analyze the association of 25(OH)D with bone mineral content (BMC) and bone mineral density (BMD); and to investigate the presence of interaction with skin color in Brazilian adults. METHODS: This is a cross-sectional, population-based study conducted with adult individuals (20-59 years) of both genders. Bone health was assessed by dual energy radiological absortometry. Vitamin D status was measured using serum 25(OH)D. Skin color and other variables in the adjusted model were collected using a questionnaire and anthropometric assessment. Associations and interactions were evaluated using linear regression models stratified according to gender. RESULTS: Non-white men with vitamin D deficiency (< 20.0 ng/mL) have less bone mass than those with insufficiency and sufficiency for the femoral neck and hip sites. According to the adjusted regression analysis, the deficient status of 25(OH)D in men was associated with worse bone health for the lumbar spine sites (β = - 0.1; p = 0.006), femoral neck (β = - 0.08; p = 0.006), and hip (β = - 0.08; p = 0.009). No statistically significant associations were observed between 25(OH)D and bone health in women. In addition, no statistical interaction was identified between skin color and vitamin D status in relation to bone health (p > 0.05 for all tests) in either gender and for all bone sites evaluated. CONCLUSION: Deficient vitamin D status is associated with lower bone mass in adults with differences observed according to gender, but not according to skin color.
Skin color has been indicated as an important factor in determining serum concentrations of 25-hydroxyvitamin D [25(OH)D], and consequently bone health. However, studies are controversial and scarce for mixed populations. PURPOSE/ INTRODUCTION: To analyze the association of 25(OH)D with bone mineral content (BMC) and bone mineral density (BMD); and to investigate the presence of interaction with skin color in Brazilian adults. METHODS: This is a cross-sectional, population-based study conducted with adult individuals (20-59 years) of both genders. Bone health was assessed by dual energy radiological absortometry. Vitamin D status was measured using serum 25(OH)D. Skin color and other variables in the adjusted model were collected using a questionnaire and anthropometric assessment. Associations and interactions were evaluated using linear regression models stratified according to gender. RESULTS: Non-white men with vitamin D deficiency (< 20.0 ng/mL) have less bone mass than those with insufficiency and sufficiency for the femoral neck and hip sites. According to the adjusted regression analysis, the deficient status of 25(OH)D in men was associated with worse bone health for the lumbar spine sites (β = - 0.1; p = 0.006), femoral neck (β = - 0.08; p = 0.006), and hip (β = - 0.08; p = 0.009). No statistically significant associations were observed between 25(OH)D and bone health in women. In addition, no statistical interaction was identified between skin color and vitamin D status in relation to bone health (p > 0.05 for all tests) in either gender and for all bone sites evaluated. CONCLUSION: Deficient vitamin D status is associated with lower bone mass in adults with differences observed according to gender, but not according to skin color.
Entities:
Keywords:
Adults, Vitamin D; Bone mineral density; Interaction; Skin color
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