Literature DB >> 3359103

Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens.

P M Dunn1, A G Blakeley.   

Abstract

The trypanocide Suramin was tested as a possible antagonist at the P2-purinoceptor of the mouse vas deferens. At a concentration of 100 microM, Suramin antagonized the response to alpha,beta-methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2-purinoceptors.

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Year:  1988        PMID： 3359103      PMCID： PMC1853806          DOI： 10.1111/j.1476-5381.1988.tb11427.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  Studies on suramin; the action of the drug on some enzymes.

Authors:  E D WILLS; A WORMALL
Journal:  Biochem J       Date:  1950-08       Impact factor: 3.857

Review 2.  Is there a basis for distinguishing two types of P2-purinoceptor?

Authors:  G Burnstock; C Kennedy
Journal:  Gen Pharmacol       Date:  1985

3.  Suramin: a potent ATPase inhibitor which acts on the inside surface of the sodium pump.

Authors:  P A Fortes; J C Ellory; V L Lew
Journal:  Biochim Biophys Acta       Date:  1973-08-22

4.  The effect of alpha, beta-methylene ATP on the depolarization evoked by noradrenaline (gamma-adrenoceptor response) and ATP in the immature rat basilar artery.

Authors:  N G Byrne; W A Large
Journal:  Br J Pharmacol       Date:  1986-05       Impact factor: 8.739

5.  Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens.

Authors:  P Sneddon; D P Westfall
Journal:  J Physiol       Date:  1984-02       Impact factor: 5.182

6.  ATP as a co-transmitter in rat tail artery.

Authors:  P Sneddon; G Burnstock
Journal:  Eur J Pharmacol       Date:  1984-10-30       Impact factor: 4.432

7.  P2-purinoceptors of two subtypes in the rabbit mesenteric artery: reactive blue 2 selectively inhibits responses mediated via the P2y-but not the P2x-purinoceptor.

Authors:  G Burnstock; J J Warland
Journal:  Br J Pharmacol       Date:  1987-02       Impact factor: 8.739

8.  Purinergic receptors: photoaffinity analog of adenosine triphosphate is a specific adenosine triphosphate antagonist.

Authors:  G K Hogaboom; J P O'Donnell; J S Fedan
Journal:  Science       Date:  1980-06-13       Impact factor: 47.728
  8 in total
  155 in total

1.  AMP is a partial agonist at the sheep cardiac ryanodine receptor.

Authors:  L L Ching; A J Williams; R Sitsapesan
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

2.  Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2.

Authors:  J Gao; J Zhao; S E Rayner; D F Van Helden
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

3.  Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells.

Authors:  A Huwiler; M Wartmann; H van den Bosch; J Pfeilschifter
Journal:  Br J Pharmacol       Date:  2000-02       Impact factor: 8.739

4.  Interaction of adenine nucleotides, UTP and suramin in mouse vas deferens: suramin-sensitive and suramin-insensitive components in the contractile effect of ATP.

Authors:  I von Kügelgen; R Bültmann; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-08       Impact factor: 3.000

5.  ATP-induced endothelium-independent enhancement of lymphatic vasomotion in guinea-pig mesentery involves P2X and P2Y receptors.

Authors:  Jun Zhao; Dirk F van Helden
Journal:  Br J Pharmacol       Date:  2002-10       Impact factor: 8.739

6.  Inhibition by nucleotides acting at presynaptic P2-receptors of sympathetic neuro-effector transmission in the mouse isolated vas deferens.

Authors:  I von Kügelgen; E Schöffel; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-11       Impact factor: 3.000

7.  Noradrenaline release from rat sympathetic neurons evoked by P2-purinoceptor activation.

Authors:  S Boehm
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

8.  Characterization of purinoceptors mediating depolarization of rat isolated vagus nerve.

Authors:  D J Trezise; I Kennedy; P P Humphrey
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

9.  Histamine and ATP mobilize calcium by activation of H1 and P2u receptors in human lens epithelial cells.

Authors:  R A Riach; G Duncan; M R Williams; S F Webb
Journal:  J Physiol       Date:  1995-07-15       Impact factor: 5.182

10.  Differential effects of suramin on P2-purinoceptors mediating contraction of the guinea-pig vas deferens and urinary bladder.

Authors:  S J Bailey; S M Hourani
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739
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