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Literature DB >> 33585401

Study on Isomeric Impurities in Cefotiam Hydrochloride.

Ye Tian¹, Xiao-Meng Chong¹, Ying Liu¹, Ying Han¹, Chang-Qin Hu¹, Shang-Chen Yao¹, Ming-Zhe Xu¹.

Abstract

In this study, two isomeric impurities were identified in cefotiam hydrochloride injection preparation and were characterized. Column-switching HPLC-MS and NMR techniques were used to identify the impurity 1 as the Δ3(4) isomers of cefotiam. Using software-based calculations, it was predicted that neither of the isomeric impurities was embryotoxic. This study provides a reference for the production, storage, and quality control of cefotiam and related cephalosporin antibiotics.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: HPLC-MS; cefotiam hydrochloride; column switching; isomer; nuclear magnetic resonance

Year: 2021 PMID： 33585401 PMCID： PMC7873999 DOI： 10.3389/fchem.2020.619307

Source DB: PubMed Journal: Front Chem ISSN： 2296-2646 Impact factor: 5.221

9 in total

1. On the isomerisation of cefozopran in solution.

Authors: Shu-Yu Liu; Dou-Sheng Zhang; Chang-Qin Hu
Journal: Eur J Med Chem Date: 2010-09-26 Impact factor: 6.514

2. [Determination of unknown impurities in cefotiam hexetil by HPLC-MS/MS].

Authors: Qun-Xing Tang; Ming-Dong Liu; You-Yi Yan; Yi Ye; Zhi-Hui Wang; Lan-Fen Zhan; Lin-Chuan Liao
Journal: Sichuan Da Xue Xue Bao Yi Xue Ban Date: 2013-05

3. Identification of a new isomer from a reversible isomerization of ceftriaxone in aqueous solution.

Authors: Ye Tian; Li Lu; Yan Chang; Dou-sheng Zhang; Jin Li; Yan-Chun Feng; Chang-Qin Hu
Journal: J Pharm Biomed Anal Date: 2014-10-02 Impact factor: 3.935

4. Isolation, identification and in silico toxicity predictions of two isomers from cefotiam hydrochloride.

Authors: Ye Tian; Ya-Nan Wang; Ying Han; Xia Zhang; Chang-Qin Hu
Journal: J Pharm Biomed Anal Date: 2018-06-18 Impact factor: 3.935

5. Degradation kinetics and isomerization of cefdinir, a new oral cephalosporin, in aqueous solution. 1.

Authors: Y Okamoto; K Kiriyama; Y Namiki; J Matsushita; M Fujioka; T Yasuda
Journal: J Pharm Sci Date: 1996-09 Impact factor: 3.534

6. Degradation kinetics and isomerization of cefdinir, a new oral cephalosporin, in aqueous solution. 2. Hydrolytic degradation pathway and mechanism for beta-lactam ring opened lactones.