Luigi Montano1, Elisabetta Ceretti2, Francesco Donato2, Paolo Bergamo3, Claudia Zani2, Gaia Claudia Viviana Viola2, Tiziana Notari4, Sebastiana Pappalardo4, Danilo Zani2, Stefania Ubaldi4, Valentina Bollati5, Claudia Consales6, Giorgio Leter6, Marco Trifuoggi7, Angela Amoresano7, Stefano Lorenzetti8. 1. Andrology Unit and Service of Lifestyle Medicine in UroAndrology, Local Health Authority (ASL) Salerno, Coordination Unit of the network for Environmental and Reproductive Health (EcoFoodFertility Project), Italy "Oliveto Citra Hospital", Salerno, Italy; PhD Program in Evolutionary Biology and Ecology, University of Rome Tor Vergata, Rome, Italy. Electronic address: l.montano@aslsalerno.it. 2. Unit of Hygiene, Epidemiology and Public Health, and Unit of Urology, Department of Medical and Surgical Specialties Radiological, University of Brescia, Brescia, Italy. 3. Institute of Food Sciences, National Research Council (CNR-ISA), Avellino, Italy. 4. Andrology Unit and Service of Lifestyle Medicine in UroAndrology, Local Health Authority (ASL) Salerno, Coordination Unit of the network for Environmental and Reproductive Health (EcoFoodFertility Project), Italy "Oliveto Citra Hospital", Salerno, Italy; PhD Program in Evolutionary Biology and Ecology, University of Rome Tor Vergata, Rome, Italy. 5. Epidemiology, Epigenetics and Toxicology (EPIGET) Lab, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. 6. Laboratory of Health and Environment, Division of Health Protection Technologies, ENEA Casaccia Research Center, Rome, Italy. 7. Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Naples, Italy. 8. Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health (ISS), Rome, Italy.
Abstract
BACKGROUND: Human semen quality is affected by lifestyle and environmental factors. OBJECTIVE: To evaluate the short-term effects of a diet and physical activity intervention on semen quality of healthy young men living in highly polluted areas of Italy. DESIGN, SETTING, AND PARTICIPANTS: A randomized controlled trial was conducted. Healthy young men were assigned to an intervention or a control group. INTERVENTION: A 4-mo Mediterranean diet and moderate physical activity program. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary outcomes were sperm concentration, motility and morphology, concentration of round cells, and semen total antioxidant capacity. Secondary outcomes were adherence to Mediterranean diet and physical activity. All outcomes were measured twice, at the enrollment (t0) and at the end of the intervention (t4). RESULTS AND LIMITATIONS: A total of 263 individuals attended all visits, and underwent examinations and laboratory analyses: 137 in the intervention group and 126 in the control group. The adherence to Mediterranean diet and physical activity level increased more in the intervention group than in the control group from t0 to t4. Sperm concentration, total and progressive motility, and proportion of normal morphology cells increased in the intervention group but decreased in the control group, with statistically significant differences between the two groups at t4. The total antioxidant capacity increased in the intervention group but decreased in the control group, from t0 to t4. CONCLUSIONS: Study results showed that an intervention based on Mediterranean diet and regular physical activity can determine an improvement of semen quality in healthy young men. PATIENT SUMMARY: Our study aimed to evaluate the effect of a lifestyle intervention on semen quality of healthy young men. We assigned the 263 enrolled individuals to an intervention or a control group. The intervention group followed a 4-mo Mediterranean diet and moderate physical activity program, at the end of which the participants showed an improvement of semen quality parameters.
BACKGROUND: Human semen quality is affected by lifestyle and environmental factors. OBJECTIVE: To evaluate the short-term effects of a diet and physical activity intervention on semen quality of healthy young men living in highly polluted areas of Italy. DESIGN, SETTING, AND PARTICIPANTS: A randomized controlled trial was conducted. Healthy young men were assigned to an intervention or a control group. INTERVENTION: A 4-mo Mediterranean diet and moderate physical activity program. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary outcomes were sperm concentration, motility and morphology, concentration of round cells, and semen total antioxidant capacity. Secondary outcomes were adherence to Mediterranean diet and physical activity. All outcomes were measured twice, at the enrollment (t0) and at the end of the intervention (t4). RESULTS AND LIMITATIONS: A total of 263 individuals attended all visits, and underwent examinations and laboratory analyses: 137 in the intervention group and 126 in the control group. The adherence to Mediterranean diet and physical activity level increased more in the intervention group than in the control group from t0 to t4. Sperm concentration, total and progressive motility, and proportion of normal morphology cells increased in the intervention group but decreased in the control group, with statistically significant differences between the two groups at t4. The total antioxidant capacity increased in the intervention group but decreased in the control group, from t0 to t4. CONCLUSIONS: Study results showed that an intervention based on Mediterranean diet and regular physical activity can determine an improvement of semen quality in healthy young men. PATIENT SUMMARY: Our study aimed to evaluate the effect of a lifestyle intervention on semen quality of healthy young men. We assigned the 263 enrolled individuals to an intervention or a control group. The intervention group followed a 4-mo Mediterranean diet and moderate physical activity program, at the end of which the participants showed an improvement of semen quality parameters.
Authors: Nadia Ferlazzo; Antonio Micali; Herbert Ryan Marini; Josè Freni; Giuseppe Santoro; Domenico Puzzolo; Francesco Squadrito; Giovanni Pallio; Michele Navarra; Santa Cirmi; Letteria Minutoli Journal: Pharmaceuticals (Basel) Date: 2021-04-21
Authors: Sabina Cauci; Michael Tavano; Francesco Curcio; Maria Pia Francescato Journal: Environ Sci Pollut Res Int Date: 2021-12-02 Impact factor: 5.190
Authors: Makiko Mitsunami; Albert Salas-Huetos; Lidia Mínguez-Alarcón; Jill A Attaman; Jennifer B Ford; Martin Kathrins; Irene Souter; Jorge E Chavarro Journal: F S Rep Date: 2021-09-02
Authors: Herbert Ryan Marini; Antonio Micali; Giovanni Squadrito; Domenico Puzzolo; José Freni; Pietro Antonuccio; Letteria Minutoli Journal: Nutrients Date: 2022-02-04 Impact factor: 5.717