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Literature DB >> 33578394

DNA- and telomere-damage does not limit lifespan: evidence from rapamycin.

Abstract

Failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal lifespan or causes normal aging.

Entities: Chemical Disease Gene Species

Keywords: antagonistic pleiotropy; hyperfunction theory; mTOR; natural selection; quasi-programmed aging

Mesh：

Substances：
Sirolimus

Year: 2021 PMID： 33578394 PMCID： PMC7906135 DOI： 10.18632/aging.202674

Source DB: PubMed Journal: Aging (Albany NY) ISSN： 1945-4589 Impact factor: 5.682

78 in total

Review 1. A critical look at proximate causes of social insect senescence: damage accumulation or hyperfunction?

Authors: Jane de Verges; Volker Nehring
Journal: Curr Opin Insect Sci Date: 2016-05-11 Impact factor: 5.186

2. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

Authors: Remi-Martin Laberge; Yu Sun; Arturo V Orjalo; Christopher K Patil; Adam Freund; Lili Zhou; Samuel C Curran; Albert R Davalos; Kathleen A Wilson-Edell; Su Liu; Chandani Limbad; Marco Demaria; Patrick Li; Gene B Hubbard; Yuji Ikeno; Martin Javors; Pierre-Yves Desprez; Christopher C Benz; Pankaj Kapahi; Peter S Nelson; Judith Campisi
Journal: Nat Cell Biol Date: 2015-07-06 Impact factor: 28.824

3. Remarkable longevity and stress resistance of nematode PI3K-null mutants.

Authors: Srinivas Ayyadevara; Ramani Alla; John J Thaden; Robert J Shmookler Reis
Journal: Aging Cell Date: 2007-11-07 Impact factor: 9.304

4. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

Authors: Fresnida J Ramos; Steven C Chen; Michael G Garelick; Dao-Fu Dai; Chen-Yu Liao; Katherine H Schreiber; Vivian L MacKay; Elroy H An; Randy Strong; Warren C Ladiges; Peter S Rabinovitch; Matt Kaeberlein; Brian K Kennedy
Journal: Sci Transl Med Date: 2012-07-25 Impact factor: 17.956

Review 5. Aging: ROS or TOR.

Authors: Mikhail V Blagosklonny
Journal: Cell Cycle Date: 2008-11-11 Impact factor: 4.534

6. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Authors: Stacey Robida-Stubbs; Kira Glover-Cutter; Dudley W Lamming; Masaki Mizunuma; Sri Devi Narasimhan; Elke Neumann-Haefelin; David M Sabatini; T Keith Blackwell
Journal: Cell Metab Date: 2012-05-02 Impact factor: 27.287

7. p53 and rapamycin are additive.

Authors: Barbara Christy; Marco Demaria; Judith Campisi; Jing Huang; Diane Jones; Sherry G Dodds; Charnae Williams; Gene Hubbard; Carolina B Livi; Xiaoli Gao; Susan Weintraub; Tyler Curiel; Z Dave Sharp; Paul Hasty
Journal: Oncotarget Date: 2015-06-30

Review 8. Answering the ultimate question "what is the proximal cause of aging?".

Authors: Mikhail V Blagosklonny
Journal: Aging (Albany NY) Date: 2012-12 Impact factor: 5.682

9. Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Authors: Simon C Johnson; Melana E Yanos; Alessandro Bitto; Anthony Castanza; Arni Gagnidze; Brenda Gonzalez; Kanav Gupta; Jessica Hui; Conner Jarvie; Brittany M Johnson; Nicolas Letexier; Lanny McCanta; Maya Sangesland; Oliver Tamis; Lauren Uhde; Alex Van Den Ende; Peter S Rabinovitch; Yousin Suh; Matt Kaeberlein
Journal: Front Genet Date: 2015-07-22 Impact factor: 4.599