Literature DB >> 18971624

Aging: ROS or TOR.

Mikhail V Blagosklonny1.   

Abstract

It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.

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Year:  2008        PMID： 18971624     DOI： 10.4161/cc.7.21.6965

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  181 in total

Review 1.  Reactive oxygen species and autophagy in plants and algae.

Authors:  María Esther Pérez-Pérez; Stéphane D Lemaire; José L Crespo
Journal:  Plant Physiol       Date:  2012-06-28       Impact factor: 8.340

Review 2.  Aging and immune function: molecular mechanisms to interventions.

Authors:  Subramaniam Ponnappan; Usha Ponnappan
Journal:  Antioxid Redox Signal       Date:  2011-01-08       Impact factor: 8.401

3.  Age-related cellular changes in the long-lived bivalve A. islandica.

Authors:  Heike Gruber; Wiebke Wessels; Primrose Boynton; Jinze Xu; Stephanie Wohlgemuth; Christiaan Leeuwenburgh; Wenbo Qi; Steven N Austad; Ralf Schaible; Eva E R Philipp
Journal:  Age (Dordr)       Date:  2015-08-29

Review 4.  Transcriptional control of antioxidant defense by the circadian clock.

Authors:  Sonal A Patel; Nikkhil S Velingkaar; Roman V Kondratov
Journal:  Antioxid Redox Signal       Date:  2014-01-03       Impact factor: 8.401

5.  Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner.

Authors:  Yi Luo; Ping Zou; Jing Zou; Jie Wang; Daohong Zhou; Lingbo Liu
Journal:  Exp Gerontol       Date:  2011-07-23       Impact factor: 4.032

6.  The Regulation of Aging and Longevity: A New and Complex Role of p53.

Authors:  Zhaohui Feng; Meihua Lin; Rui Wu
Journal:  Genes Cancer       Date:  2011-04

7.  mTORC1 and p53: clash of the gods?

Authors:  Paul Hasty; Zelton Dave Sharp; Tyler J Curiel; Judith Campisi
Journal:  Cell Cycle       Date:  2013-01-01       Impact factor: 4.534

8.  Impaired autophagic function in rat islets with aging.

Authors:  Yu Liu; Suozhu Shi; Zhaoyan Gu; Yingzhen Du; Minyan Liu; Shuangtong Yan; Jianjun Gao; Jian Li; Yinghong Shao; Wenwen Zhong; Xiangmei Chen; Chunlin Li
Journal:  Age (Dordr)       Date:  2012-07-28

Review 9.  Ionizing radiation and aging: rejuvenating an old idea.

Authors:  Richard B Richardson
Journal:  Aging (Albany NY)       Date:  2009-11-17       Impact factor: 5.682

Review 10.  Effect of feeding regimens on circadian rhythms: implications for aging and longevity.

Authors:  Oren Froy; Ruth Miskin
Journal:  Aging (Albany NY)       Date:  2010-12-11       Impact factor: 5.682
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