Literature DB >> 33572794

Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity.

Claudio Zippilli1, Lorenzo Botta1, Bruno Mattia Bizzarri1, Lucia Nencioni2, Marta De Angelis2, Virginia Protto2, Gianluca Giorgi3, Maria Camilla Baratto3, Rebecca Pogni3, Raffaele Saladino1.   

Abstract

Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.

Entities:  

Keywords:  1,4-dioxane; EPR; N-oxides; Oxizymes; belladine derivatives; influenza A virus; laccase

Mesh：

Substances：

Year:  2021        PMID： 33572794      PMCID： PMC7866262          DOI： 10.3390/ijms22031337

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  24 in total

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Authors:  Guanqun Zhan; Junfei Zhou; Rong Liu; Tingting Liu; Guoli Guo; Jianping Wang; Ming Xiang; Yongbo Xue; Zengwei Luo; Yonghui Zhang; Guangmin Yao
Journal:  J Nat Prod       Date:  2016-02-25       Impact factor: 4.050

2.  In-silico profiling of the biological activities of Amaryllidaceae alkaloids.

Authors:  Eman Shawky
Journal:  J Pharm Pharmacol       Date:  2017-08-15       Impact factor: 3.765

3.  Detoxication mechanisms. 3. The scope and mechanism of the iron-catalyzed dealkylation of tertiary amine oxides.

Authors:  J P Ferris; R D Gerwe; G R Gapski
Journal:  J Org Chem       Date:  1968-09       Impact factor: 4.354

4.  Transformation of atenolol by a laccase-mediator system: Efficiencies, effect of water constituents, and transformation pathways.

Authors:  Yiping Feng; Mengyao Shen; Zhu Wang; Guoguang Liu
Journal:  Ecotoxicol Environ Saf       Date:  2019-08-13       Impact factor: 6.291

5.  Pseudolycorine N-oxide, a new N-oxide from Narcissus tazetta.

Authors:  Deepali Katoch; Dharmesh Kumar; Yogendra S Padwad; Bikram Singh; Upendra Sharma
Journal:  Nat Prod Res       Date:  2019-02-20       Impact factor: 2.861

6.  Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes.

Authors:  Roberta Meschini; Donatella D'Eliseo; Silvia Filippi; Laura Bertini; Bruno Mattia Bizzarri; Lorenzo Botta; Raffaele Saladino; Francesca Velotti
Journal:  J Agric Food Chem       Date:  2018-11-07       Impact factor: 5.279

7.  Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.

Authors:  C U Kim; W Lew; M A Williams; H Liu; L Zhang; S Swaminathan; N Bischofberger; M S Chen; D B Mendel; C Y Tai; W G Laver; R C Stevens
Journal:  J Am Chem Soc       Date:  1997-01-29       Impact factor: 15.419

8.  Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase.

Authors:  Abdullah Al Mamun; Jana Maříková; Daniela Hulcová; Jiří Janoušek; Marcela Šafratová; Lucie Nováková; Tomáš Kučera; Martina Hrabinová; Jiří Kuneš; Jan Korábečný; Lucie Cahlíková
Journal:  Biomolecules       Date:  2020-05-22

Review 9.  Laccase Properties, Physiological Functions, and Evolution.

Authors:  Grzegorz Janusz; Anna Pawlik; Urszula Świderska-Burek; Jolanta Polak; Justyna Sulej; Anna Jarosz-Wilkołazka; Andrzej Paszczyński
Journal:  Int J Mol Sci       Date:  2020-01-31       Impact factor: 5.923

10.  The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection.

Authors:  M E Marcocci; D Amatore; M L Mangoni; L Nencioni; S Villa; B Casciaro; P Aimola; G Franci; P Grieco; M Galdiero; A T Palamara
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191
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  1 in total

1.  Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity.

Authors:  Bruno Mattia Bizzarri; Angelica Fanelli; Lorenzo Botta; Marta De Angelis; Anna Teresa Palamara; Lucia Nencioni; Raffaele Saladino
Journal:  RSC Adv       Date:  2021-09-08       Impact factor: 4.036
  1 in total

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